View source for Gold toxicity

==Background==
*Gold is sometimes administered (as gold sodium thiomalate or Auranofin) IM/IV to treat [[rheumatoid arthritis]] and other autoimmune diseases
*Use limited by significant adverse effect profile, including toxicity, and need for close monitoring

==Clinical Features==
*Mucocutaneous effects- most common
**Dermatitis, [[pruritus]], [[urticaria]], stomatitis
**Less common: alopecia, trophic nails, pseudocyanosis (non-blanching blue-grey skin discoloration; spares mucous membranes, may be more pronounced where sun-exposed)
*Metallic taste
*[[Diarrhea]], entero[[colitis]] (mild symptoms common, sometimes severe)
*[[Proteinuria]]/membranous [[glomerulonephritis]] (common), [[nephrotic syndrome]] (rare)
*Post-injection vasomotor reaction +/- anaphylaxis, syncope (rare)
*[[Eosinophilia]] (common)
*Cytopenias, [[aplastic anemia]] (rare)
*[[Hepatotoxicity]], [[pancreatitis]] (rare)
*[[Encephalopathy]], peripheral/cranial neuropathies (rare)
*Interstitial pneumonitis (rare)

==Differential Diagnosis==
{{Heavy metals list}}

==Evaluation==
*CBC, BMP, [[LFTs]], UA
*Assess for alternative diagnoses

==Management==
*Supportive care
*Most symptoms improve with cessation of gold therapy

==Disposition==


==See Also==
*[[Heavy metal toxicity]]

==External Links==


==References==
<references/>
*UpToDate, Tintinalli's
[[Category:Toxicology]]