Dopamine: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "α1" to "α<sub>1</sub>") |
Neil.m.young (talk | contribs) (Text replacement - "β1" to "β<sub>1</sub>") |
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| Line 8: | Line 8: | ||
*Low dose: | *Low dose: | ||
**1-5 mcg/kg/min - Vasodilation (renal, mesenteric, coronary) | **1-5 mcg/kg/min - Vasodilation (renal, mesenteric, coronary) | ||
**5-10 mcg/kg/min - predominant | **5-10 mcg/kg/min - predominant β<sub>1</sub> | ||
*High dose: 10-20 mcg/kg/min - predominant α<sub>1</sub> | *High dose: 10-20 mcg/kg/min - predominant α<sub>1</sub> | ||
*Titrate to clinical effect | *Titrate to clinical effect | ||
| Line 51: | Line 51: | ||
*Mechanism of Action: | *Mechanism of Action: | ||
===Primary Receptor=== | ===Primary Receptor=== | ||
*Low dose: DA, | *Low dose: DA, β<sub>1</sub> | ||
*High dose: DA, α<sub>1</sub> >> | *High dose: DA, α<sub>1</sub> >> β<sub>1</sub> | ||
===Relative Effects=== | ===Relative Effects=== | ||
*Low dose: Natriuresis, ↑↑HR, ↑↑SV | *Low dose: Natriuresis, ↑↑HR, ↑↑SV | ||
Revision as of 07:48, 10 August 2017
General
- Type: Vasopressors
- Dosage Forms: IV
- Common Trade Names: Intropin
Adult Dosing
Dosing
- Low dose:
- 1-5 mcg/kg/min - Vasodilation (renal, mesenteric, coronary)
- 5-10 mcg/kg/min - predominant β1
- High dose: 10-20 mcg/kg/min - predominant α1
- Titrate to clinical effect
- Use lowest dose possible (prevent tachyphylaxis)
- May use in peripheral IV temporarily
- Avoid using in same line as alkaline infusions
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating: Class C
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- Tachyarrhythmias
Adverse Reactions
- Low doses:
- Hypotension
- High doses:
- Hypertension, ectopic beats
- Tissue necrosis (if extravasates)
- If occurs use phentolamine 5-10mg in affected area
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- Low dose: DA, β1
- High dose: DA, α1 >> β1
Relative Effects
- Low dose: Natriuresis, ↑↑HR, ↑↑SV
- High dose: ↑SVR and ↑SV
Notes
Indications
- Hypotensioncaused by:
- Septic shock
- MI
- Trauma/spinal shock
- Heart failure