Leukopenia: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
*Immunosuppression--> increase risk of infection, including opportunistic pathogens | |||
*+/- signs/symptoms of underlying disease | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*Malignancy (infiltration in [[leukemia]], [[myeloproliferative disorders]] or bony metastases) | |||
*[[B12 deficiency|B12]] or [[folate deficiency]] | |||
*[[Aplastic anemia]] | |||
*Infection | |||
**[[Sepsis]] | |||
**Acute viral infection (e.g. [[URI]], [[influenza]], [[HIV]]) | |||
**[[HIV]]/[[AIDS]] | |||
**[[Typhoid]], [[dengue]], [[malaria]], [[rickettsia]], [[lyme]] | |||
*Autoimmune disorders (e.g. [[SLE]], [[Crohn's]], [[RA]]) | |||
*Drugs/tox | |||
**Chemotherapeutics (antineoplastics, [[hydroxyurea]], [[methotrexate]]) | |||
**[[Radiation exposure]] | |||
**[[Clozapine]], [[chlorpromazine]] | |||
**[[Phenytoin]] | |||
**[[Sulfonamides]], [[penicillin]], [[cephalosporins]], antiretrovirals | |||
**[[Cimetidine]] | |||
*Hypersplenism/splenic sequestration | |||
*Miscellaneous | |||
**Congenital, cyclic, "chronic benign neutropenia" | |||
==Evaluation== | ==Evaluation== | ||
*Assess for infection | |||
*Further evaluation dependant on presentation | |||
==Management== | ==Management== | ||
*Low threshold for empiric antimicrobials if any concern for infection | |||
*May need only outpatient specialist referral if otherwise asymptomatic | |||
==Disposition== | ==Disposition== | ||
*Dependant on presentation | |||
==See Also== | ==See Also== | ||
*[[Pancytopenia]] | |||
*[[Neutropenia]] | |||
*[[Immunocompromised antibiotics]] | |||
*[[Aplastic anemia]] | |||
==External Links== | ==External Links== | ||
Latest revision as of 17:41, 15 August 2019
Background
- Low or absent white blood cell count
- Neutropenia is a subset
Clinical Features
- Immunosuppression--> increase risk of infection, including opportunistic pathogens
- +/- signs/symptoms of underlying disease
Differential Diagnosis
- Malignancy (infiltration in leukemia, myeloproliferative disorders or bony metastases)
- B12 or folate deficiency
- Aplastic anemia
- Infection
- Autoimmune disorders (e.g. SLE, Crohn's, RA)
- Drugs/tox
- Chemotherapeutics (antineoplastics, hydroxyurea, methotrexate)
- Radiation exposure
- Clozapine, chlorpromazine
- Phenytoin
- Sulfonamides, penicillin, cephalosporins, antiretrovirals
- Cimetidine
- Hypersplenism/splenic sequestration
- Miscellaneous
- Congenital, cyclic, "chronic benign neutropenia"
Evaluation
- Assess for infection
- Further evaluation dependant on presentation
Management
- Low threshold for empiric antimicrobials if any concern for infection
- May need only outpatient specialist referral if otherwise asymptomatic
Disposition
- Dependant on presentation