Chlorate toxicity: Difference between revisions
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==Background== | ==Background== | ||
*Potassium | *Potassium chlorate, barium chlorate, and sodium chlorate found in fireworks, match heads, and weed killers | ||
===Mechanism of Toxicity=== | ===Mechanism of Toxicity=== | ||
| Line 16: | Line 15: | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
== | ==Evaluation== | ||
* | *Co-oximetry | ||
*No specific levels are available | *Additional evaluation based on clinical presentation and presence of methemoglobinemia | ||
*No specific serum levels are available | |||
==Management== | ==Management== | ||
| Line 25: | Line 25: | ||
*[[Sodium thiosulfate]] IV may inactivate chlorate ions (anecdotal) | *[[Sodium thiosulfate]] IV may inactivate chlorate ions (anecdotal) | ||
*Hemodialysis | *Hemodialysis | ||
*Supportive | *Supportive care | ||
==Disposition== | ==Disposition== | ||
| Line 33: | Line 33: | ||
==References== | ==References== | ||
Olson, K. Poisoning and Drug Overdose, 1999. | Olson, K. Poisoning and Drug Overdose, 1999. | ||
[[Category:Toxicology]] | |||
Latest revision as of 21:57, 20 August 2019
Background
- Potassium chlorate, barium chlorate, and sodium chlorate found in fireworks, match heads, and weed killers
Mechanism of Toxicity
- Oxidizers and attackers of sulfhydryl groups
- Cause methemoglobin formation
Clinical Presentation
Differential Diagnosis
Evaluation
- Co-oximetry
- Additional evaluation based on clinical presentation and presence of methemoglobinemia
- No specific serum levels are available
Management
- Activated charcoal IS recommended
- Methylene blue for methemoglobinemia (1-2 mg/kg of 1% solution)
- Sodium thiosulfate IV may inactivate chlorate ions (anecdotal)
- Hemodialysis
- Supportive care
Disposition
External Links
References
Olson, K. Poisoning and Drug Overdose, 1999.