Pantoprazole: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[Upper gastrointestinal bleeding]]=== | ===[[Upper gastrointestinal bleeding]]=== | ||
*80mg x 1; then 8mg/hr | *80mg IV x 1; then 8mg/hr OR 80mg IV BID | ||
===[[GERD]], [[Peptic ulcer disease]], [[Esophagitis]]=== | |||
*40mg IV or PO daily | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*<5yo: safety/efficacy not established | |||
*>5yo | |||
**15 kg to <40 kg: 20 mg PO qDay | |||
**40 kg or greater: 40 mg PO qDay | |||
==Special Populations<ref>Pantoprazole: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>== | ==Special Populations<ref>Pantoprazole: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | ||
*Lactation: | *Lactation: | ||
** Pantoprazole is present in breast milk | ** Pantoprazole is present in breast milk | ||
| Line 55: | Line 61: | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:GI]] | |||
Revision as of 21:19, 23 September 2019
General
- Type: Proton-pump inhibitor
- Dosage Forms:
- Common Trade Names: Protonix, Somac, Forppi, Pantoloc, Pantozol, Pantomed, Zurcal, Zentro, Pan, Controloc, Tecta
Adult Dosing
Upper gastrointestinal bleeding
- 80mg IV x 1; then 8mg/hr OR 80mg IV BID
GERD, Peptic ulcer disease, Esophagitis
- 40mg IV or PO daily
Pediatric Dosing
- <5yo: safety/efficacy not established
- >5yo
- 15 kg to <40 kg: 20 mg PO qDay
- 40 kg or greater: 40 mg PO qDay
Special Populations[1]
- Pregnancy Rating: B
- Lactation:
- Pantoprazole is present in breast milk
- Renal Dosing
- Adult
- No adjustment necessary
- Pediatric
- Not defined
- Adult
- Hepatic Dosing
- Adult
- No adjustment necessary
- Pediatric
- Not defined
- Adult
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- anaphylaxis
- SJS/TEN
- Renal impairment
- pancreatitis
- hepatic impairment
Common
- Headache
- abdominal pain
- nausea/vomiting/diarrhea
- AST/ALT elevation
Pharmacology
- Half-life: 1 hour
- Metabolism: Hepatic - CYP450
- Excretion: Urine/Feces
- Mechanism of Action: inhibits gastric parietal cell H+/K+ ATPase
See Also
References
- ↑ Pantoprazole: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.