Pantoprazole

General

• Type: Proton-pump inhibitor
• Dosage Forms:
• Common Trade Names: Protonix, Somac, Forppi, Pantoloc, Pantozol, Pantomed, Zurcal, Zentro, Pan, Controloc, Tecta

Adult Dosing

Upper gastrointestinal bleeding

• 80mg IV x 1; then 8mg/hr OR 80mg IV BID
• Intermittent dosing is comparable to bolus then continuous drip

GERD, Peptic ulcer disease, Esophagitis

• 40mg IV or PO daily

Pediatric Dosing

• <5yo: safety/efficacy not established
• >5yo
  • 15 kg to <40 kg: 20 mg PO qDay
  • 40 kg or greater: 40 mg PO qDay

Special Populations

• Pregnancy Rating: B
• Lactation:
  • Pantoprazole is present in breast milk
• Renal Dosing
  • Adult
    • No adjustment necessary
  • Pediatric
    • Not defined
• Hepatic Dosing
  • Adult
    • No adjustment necessary
  • Pediatric
    • Not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Anaphylaxis
• SJS/TEN
• Renal impairment
• Pancreatitis
• Hepatic impairment

Common

• Headache
• abdominal pain
• nausea/vomiting/diarrhea
• AST/ALT elevation

Pharmacology

• Half-life: 1 hour
• Metabolism: Hepatic - CYP450
• Excretion: Urine/Feces
• Mechanism of Action: inhibits gastric parietal cell H+/K+ ATPase