Template:Table of severe drug reactions: Difference between revisions
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| Mucocutaneous features||Facial edema, morbilliform eruption, pustules, exfoliative dermattiis, tense bullae, possible target lesions||Bullae, atypical target lesions, mucocutaneous erosions||Facial edema, pustules, tense bullae, possible target lesions, possibl emucosal involvement||Erythematous plaques and edema affecting >90% of total skin surface with or without diffuse exfoliation | | Mucocutaneous features||Facial edema, morbilliform eruption, pustules, exfoliative dermattiis, tense bullae, possible target lesions||Bullae, atypical target lesions, mucocutaneous erosions||Facial edema, pustules, tense bullae, possible target lesions, possibl emucosal involvement||Erythematous plaques and edema affecting >90% of total skin surface with or without diffuse exfoliation | ||
|- | |- | ||
| | | Lymph node enlargement||+++||-||+||+ | ||
|- | |||
| Neutrophils||Elevated||Decreased||Very elevated||Elevated | |||
|- | |- | ||
| | | Eosinophils||Very elevated||No change||Elevated||Elevated | ||
|- | |- | ||
| | | Atypical lymphocytes||+||-||-||+ | ||
|- | |- | ||
| Hepatitis||+++||++||++||- | | Hepatitis||+++||++||++||- | ||
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| Other organ involvement||Interstitial nephritis, pneumonitis, myocarditis, and thydoiditis||Tubular nephritis and tracheobronical necrosis||Possible||Possible | | Other organ involvement||Interstitial nephritis, pneumonitis, myocarditis, and thydoiditis||Tubular nephritis and tracheobronical necrosis||Possible||Possible | ||
|- | |- | ||
| | | Histological pattern of skin||Perivascular lymphocytcic infiltrate||Epidermal necrosis||Subcorneal pustules||Nonspecific, unless reflecting Sezary syndrome or other lymphoma | ||
|- | |- | ||
| | | Lymph node histology||Lymphoid hyperplasia||-||-||No, unless reflecting Sezary syndrome or other malignancy | ||
|- | |||
|- | |- | ||
| Mortality (%)||10||5-35||5||5-15 | | Mortality (%)||10||5-35||5||5-15 | ||
Revision as of 19:14, 17 December 2019
Table of Severe Drug Reactions
| Charateristic | DRESS | SJS/TEN | AGEP | Erythroderma |
| Onset of eruption | 2-6 weeks | 1-3 weeks | 48 hours | 1-3 weeks |
| Duration of eruption (weeks) | Several | 1-3 | <1 | Several |
| Fever | +++ | +++ | +++ | +++ |
| Mucocutaneous features | Facial edema, morbilliform eruption, pustules, exfoliative dermattiis, tense bullae, possible target lesions | Bullae, atypical target lesions, mucocutaneous erosions | Facial edema, pustules, tense bullae, possible target lesions, possibl emucosal involvement | Erythematous plaques and edema affecting >90% of total skin surface with or without diffuse exfoliation |
| Lymph node enlargement | +++ | - | + | + |
| Neutrophils | Elevated | Decreased | Very elevated | Elevated |
| Eosinophils | Very elevated | No change | Elevated | Elevated |
| Atypical lymphocytes | + | - | - | + |
| Hepatitis | +++ | ++ | ++ | - |
| Other organ involvement | Interstitial nephritis, pneumonitis, myocarditis, and thydoiditis | Tubular nephritis and tracheobronical necrosis | Possible | Possible |
| Histological pattern of skin | Perivascular lymphocytcic infiltrate | Epidermal necrosis | Subcorneal pustules | Nonspecific, unless reflecting Sezary syndrome or other lymphoma |
| Lymph node histology | Lymphoid hyperplasia | - | - | No, unless reflecting Sezary syndrome or other malignancy |
| Mortality (%) | 10 | 5-35 | 5 | 5-15 |
- AGEP Acute generalized exanthematous pustulosis
- DRESS drug reaction with eosinophilia and systemic symptoms
- SJS Stevens-Johnson syndrome
- TEN toxic epidermal necrolysis