Chlorpromazine: Difference between revisions

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==Administration==
==Administration==
*Dosage Forms: 25 mg/mL IV solution; 25 mg/5 mL oral solution; 10, 25, and 100 mg tablets
*Type: [[Antipsychotic]], first generation
*Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets
*Routes of Administration: PO, IM, IV
*Routes of Administration: PO, IM, IV
*Common Trade Names: Thorazine
*Common Trade Names: Thorazine
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==Adult Dosing==
==Adult Dosing==
===[[Nausea/vomiting]]===
===[[Nausea/vomiting]]===
*Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary.  
*Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary.  
*IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.  
*IM: 25mg one time. If no hypotension occurs, give 25 to 50mg every 3 to 4 hours as needed, then switch to oral dosage.  
*IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1 mg/mL.
*IV: 2mg at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.


===[[Hiccups]]===
===[[Hiccups]]===
*Oral: 25 to 50 mg 3 to 4 times a day
*Oral: 25 to 50mg 3 to 4 times a day
*IM: If symptoms persist for 2 to 3 days, give 25 to 50 mg IM
*IM: If symptoms persist for 2 to 3 days, give 25 to 50mg IM
*IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50 mg in 500 to 1000 mL of saline.
*IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50mg in 500 to 1000 mL of saline.


===[[Psychosis]]===
===[[Psychosis]]===
*IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.  
*IM: Initial Dose 25 to 50mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.  
*Oral: Initial Dose: 10 to 25 mg orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.
*Oral: Initial Dose: 10 to 25mg orally 3 times a day. Total daily doses should be increased in 20 to 50mg increments every 3 or 4 days until symptoms are controlled.
*Usual Maintenance Dose: 200 mg/day orally
*Usual Maintenance Dose: 200mg/day orally


==Pediatric Dosing==
==Pediatric Dosing==
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===[[Nausea/vomiting]]===
===[[Nausea/vomiting]]===
*Oral: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed.  
*Oral: 0.5 to 1mg/kg/dose every 4 to 6 hours as needed.  
*IM or IV: 0.5 to 1 mg/kg/dose every 6 to 8 hours
*IM or IV: 0.5 to 1mg/kg/dose every 6 to 8 hours


===Maximum recommended doses===
===Maximum recommended doses===
*less than 5 years (less than 22.7 kg): 40 mg/day
*less than 5 years (less than 22.7 kg): 40mg/day
*5 and older (22.7-45.5 kg): 75 mg/day
*5 and older (22.7-45.5 kg): 75mg/day


==Special Populations==
==Special Populations==
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==Adverse Reactions==
==Adverse Reactions==
*Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.
*Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.
==See Also==
*[[Antipsychotic toxicity]]


==References==
==References==
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[[Category:Pharmacology]]
[[Category:Pharmacology]]
[[Category:Psychiatry]]

Latest revision as of 04:07, 7 March 2021

Administration

  • Type: Antipsychotic, first generation
  • Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets
  • Routes of Administration: PO, IM, IV
  • Common Trade Names: Thorazine

Adult Dosing

Nausea/vomiting

  • Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary.
  • IM: 25mg one time. If no hypotension occurs, give 25 to 50mg every 3 to 4 hours as needed, then switch to oral dosage.
  • IV: 2mg at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.

Hiccups

  • Oral: 25 to 50mg 3 to 4 times a day
  • IM: If symptoms persist for 2 to 3 days, give 25 to 50mg IM
  • IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50mg in 500 to 1000 mL of saline.

Psychosis

  • IM: Initial Dose 25 to 50mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.
  • Oral: Initial Dose: 10 to 25mg orally 3 times a day. Total daily doses should be increased in 20 to 50mg increments every 3 or 4 days until symptoms are controlled.
  • Usual Maintenance Dose: 200mg/day orally

Pediatric Dosing

should not be used in children under 6 months

Nausea/vomiting

  • Oral: 0.5 to 1mg/kg/dose every 4 to 6 hours as needed.
  • IM or IV: 0.5 to 1mg/kg/dose every 6 to 8 hours

Maximum recommended doses

  • less than 5 years (less than 22.7 kg): 40mg/day
  • 5 and older (22.7-45.5 kg): 75mg/day

Special Populations

Indications

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.

See Also

References

  1. Chlorpromazine. Retrieved from http://www.drugs.com/cdi/chlorpromazine.html
  2. US National Library of Medicine. Chlorpromazine: MedlinePlus Drug Information. Retrieved from https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682040.html.
  3. P Young. The ICU Drug Manual. Chlorpromazine. Retrieved from http://lifeinthefastlane.com/book/critical-care-drugs/chlorpromazine/
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