Uric acid crystalluria: Difference between revisions
Patricklin (talk | contribs) (Created page with "==Background== *Common cause of red, pink, or orange urine in neonates **Occurs mostly in the first week of life, but can occur anytime during infancy *Parents often confuse this phenomenon with blood, leading to presentation to ED<ref>Küpeli S, Yurdakök M, Kilinc G, Bilgetekin E. Urinary uric acid levels and discoloration of diapers in healthy neonates. Pediatr Nephrol. 2005 Sep;20(9):1361-2. doi: 10.1007/s00467-005-1934-5. Epub 2005 Jun 8. PMID: 15942785.</ref> *Oft...") |
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{{Template:Pediatric hematuria DDX}} | {{Template:Pediatric hematuria DDX}} | ||
==Workup== | ==Evaluation== | ||
*Clinical diagnosis | ===Workup=== | ||
*[[UA]] | |||
===Diagnosis=== | |||
*Clinical diagnosis | |||
==Management== | ==Management== | ||
*Reassurance | *Reassurance | ||
**No further workup indicated, unless alternate causes are suspected | |||
==Disposition== | ==Disposition== | ||
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==See Also== | ==See Also== | ||
[ | *[[Abnormally colored urine]] | ||
==External Links== | ==External Links== | ||
*[https://www.consultant360.com/articles/pediatric-urology-clinics-reddish-urine-stain-diaper-3-week-old-boy pediatric-urology-clinics-reddish-urine-stain-diaper] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pediatrics]] | |||
Latest revision as of 20:34, 24 January 2024
Background
- Common cause of red, pink, or orange urine in neonates
- Occurs mostly in the first week of life, but can occur anytime during infancy
- Parents often confuse this phenomenon with blood, leading to presentation to ED[1]
- Often due to dehydration and relative immaturity of kidney's concentrating abilities
- Breastfeeding may increase uric acid crystalluria due to its high protein content, which acidifies urine and promotes urate crystallization
Clinical Features
- Reddish, pink, or orange urine noted in diaper
- History of breast-feeding and/or dehydration
- Baby is otherwise well-appearing (suspect alternate diagnoses if has colicky symptoms or febrile)
Differential Diagnosis
- For female neonates, consider withdrawal bleeding due to lack of maternal hormones
- Consider other serious causes, including obstructive uropathies, porphyria, familial/genetic causes of hyperuricemia[2]
- Consider foods or medications: beets, rifampin, multivitamins, pyridium, etc
Pediatric Hematuria
| Macroscopic Hematuria | Transient Microhematuria | Persistent Microhematuria |
| Blunt abdominal trauma | Strenuous exercise | Benign familial hematuria |
| Urinary tract infection | Congenital anomalies | Idiopathic hypercalciuria |
| Nephrolithiasis | Trauma | Immunoglobulin A nephropathy |
| Infections | Menstruation | |
| Poststreptococcal glomerulonephritis | Bladder catheterization | Alport syndrome |
| High fever | Sickle cell trait or anemia | |
| Immunoglobulin A nephropathy | Henoch-Schonlein purpura | |
| Hypercalciuria | Drugs and toxins | |
| Sickle cell disease | Lupus nephritis |
Look-Alikes
- Foods or medications
- Uric acid crystalluria
- Gastrointestinal bleeding (peds)
- Vaginal bleeding
- Other causes of abnormally colored urine
Evaluation
Workup
Diagnosis
- Clinical diagnosis
Management
- Reassurance
- No further workup indicated, unless alternate causes are suspected
Disposition
- Discharge
See Also
External Links
References
- ↑ Küpeli S, Yurdakök M, Kilinc G, Bilgetekin E. Urinary uric acid levels and discoloration of diapers in healthy neonates. Pediatr Nephrol. 2005 Sep;20(9):1361-2. doi: 10.1007/s00467-005-1934-5. Epub 2005 Jun 8. PMID: 15942785.
- ↑ 1. Jeng JY, Franz WB. Orange Stains in a Healthy Neonate’s Diaper. Clinical Pediatrics. 2014;53(9):908-910. doi:10.1177/0009922814536777