Isoproterenol: Difference between revisions
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Latest revision as of 21:55, 20 March 2026
General
- Type: Beta agonist; Antiarrhythmics
- Dosage Forms: IV or IM injection
- Common Trade Names: Isoprenaline, Isuprel
Adult Dosing
- Loading dose: 0.02-0.06 mg IV, followed by infusion[1][2]
- 2-20 mcg/min IV infusion
- Titrate to HR and BP
- Alternatively, bolus 0.02-0.06 mg IV, then 0.01-0.2 mg IV PRN
Pediatric Dosing
- No well controlled studies for appropriate dosing
- AHA recommends initial infusion of 0.1 mcg/kg/min, with titrated range usually 0.1-1 mcg/kg/min[3]
Special Populations
- Pregnancy Rating: C
- Lactation risk: Unknown
- Renal Dosing - undefined
- Hepatic Dosing - undefined
Indications
- Refractory torsades
- Refractory symptomatic bradycardia
- Refractory electrical storm
- Brugada syndrome
Contraindications
- Allergy to class/drug
Adverse Reactions
- Dramatic increase in O2 demand
- V-tach (use lowest dose possible)
Pharmacology
- Half-life: 2-10 min[4]
- Metabolism: liver, CYP450
- Excretion: urine primarily
- Mechanism of Action: Beta adrenergic agonist
Kinetics
- Onset of action = 1-5 min
- Duration of action = 1-2 hr
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Electrical storm | 2mcg/min IV infusion, titrate to HR 90-100 | Torsades or Brugada syndrome | IV | Adult |
| Polymorphic ventricular tachycardia | 2-8mcg/min IV infusion | Torsades de pointes | IV | Adult |
| Torsades de pointes | 2-8mcg/min | Increases HR/AV conduction; target HR >90 bpm | IV | Adult |
See Also
References
- ↑ GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.
- ↑ AthenaHealth. Epocrates. Isoproterenol - Entire Monograph. https://online.epocrates.com/u/10a106/isoproterenol.
- ↑ GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.
- ↑ Hadwiger ME et al. Simultaneous determination of the elimination profiles of the individual enantiomers of racemic isoproterenol using capillary electrophoresis and microdialysis sampling. J Pharm Biomed Anal. 1997 Feb;15(5):621-9.