Iron toxicity: Difference between revisions
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Revision as of 14:19, 25 August 2015
Background
- The toxicity is generally determined by the mg/kg of elemental iron ingested. The total amount of elemental iron ingested can calculated by multiplying the estimated number of tablets by the percentages of iron in the tablet preparation. Clinical severity is based approximated by the following elemental dose per kilograms:[1]
| Mild: | 10-20mg/kg |
| Moderate | 20-60mg/kg |
| Severe | >60mg/kg |
- Absence of GI symptoms w/in 6hr of ingestion excludes significant iron ingestion
- Significant iron toxicity can result in a severe lactic acidosis from hypopefusion due to volume loss, vasodilation and negative inotropin effects.
Elemental Iron Percentages
Elemental Iron Percentages
| Iron Preparation | % of Elemental Iron |
| Ferrous Fumarate | 33% |
| Ferrous Sulfate | 20% |
| Ferrous Gluconate | 12% |
| Ferric pyrophosphate | 30% |
| Ferroglycine sulfate | 16% |
| Ferrous carbonate (anhydrous) | 38% |
Pathophysiology
Direct caustic injury to gastric mucosa[2]
- Causing vomitting, diarrhea, abdominal pain, and bleeding
Impaired cellular metabolism
- Inhibiting the electron transport chain causes lactic acidosis
- Direct hepatic, CNS, and cardiac toxicity
- Cell membrane injury from lipid peroxidation[3]
Increased capillary permeability
- Hypotension
- Venodilation
Portal vein iron delivery to liver
- Hepatotoxicity
Thrombin formation inhibition
- Coagulopathy - direct effect on vitamin K clotting factors
Clinical Features
| Stage | Clinical Effect | Time Frame |
|---|---|---|
| Stage 1 | GI irritation: n/v, abd pain, diarrhea | 30-60 mins |
| Stage 2: latent | reduced GI symptoms | 6-24 hours |
| Stage 3: shock and metabolic acidosis | metabolic acidosis, lactic acidosis, dehydration, coags, renal failure | 6-72 hours |
| Stage 4: hepatotox | hepatic failure | 12-96 hours |
| Stage 5: bowel obstruction | GI bowel scarring/healing | 2-8 weeks |
Diagnosis
Work-Up
- CBC
- Chemistry
- Anion gap metabolic acidosis
- Hyperglycemia
- Coags
- LFTs
- Iron levels
- UA
- Used to follow efficacy of Fe chelation (urine changes from rusty color to clear)
- Type and Screen
- In ambiguous cases consider abd xray as most Fe tabs are radioopague
Serum Iron Concentration
Serum Iron concentration can guide treatment but are not absolute in predicting or excluding toxicity: Peak serum iron level:
- <300 mcg/dL: nontoxic or mild
- 300-500 mcg/dL: Significant GI symptoms and potential for systemic toxicity
- >500 mcg/dL: Moderate to severe systemic toxicity
- >1000 mcg/dL: severe systemic toxicity and increased morbidity
If unable to obtain a serum iron level a glucose > 150 mg/dL and leukocyte count above 15000 is 100% specific and 50% sensitive in predicint=g levels > 300mcg/mL[4]
Management
Observation x 6 hrs
- Patients with asymptomatic ingestion of <20mg/kg only require observation x 6hr
- Volume resuscitation
GI decontamination
- Consider only for large overdose with visible pills in the stomach on x-ray
- Whole-bowel irrigation (polyethylene glycol) will promote increased gastric emptying and avoid large bezoar formation[5]
Polyethylene glycol dosing
Can be given orally or by NG tube
- 20-40 mL/kg/hr in young children
- 2L/hr in adults
Continue irrigation until the rectal effluent is clear
Deferoxamine
Deferoxamine chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.[1]
Indications
- Systemic toxicity and iron level > 350 mcg/dL
- Metabolic acidosis
- Progressive symptoms
- Serum iron level >500 mcg/dL
Dosing
- 1000mg IV; start at 5mg/kg/hr, increase up to 15mg/kg/hr as tolerated for up to 24hrs
- Subsequent doses are 500mg increments guided by clinical status of pt / urine color
- Recommended amount during first 24hr is 360mg/kg not to exceed 6g.
Adverse effects
- Hypotension (pre-existing hypotension is NOT a contraindication to therapy)
- ARDS
- Yersinia enterocolitica sepsis[6]
- Can see "vin rose" colored urine from chelated iron extretion
Contraindications
- Renal failure patients not on hemodialysis
Hemodialysis
- Not effective in removing iron due to large volumes of distribution
- Dialysis can removes deferoxamine-iron complex in renal failure patients
Exchange Transfusion
- Minimal evidence but has been described in larger overdoses[7]
Orogastric lavage
- Does not remove large numbers of pills and may have serious adverse events
Activated charcoal
- Does not bind iron
Disposition
- Discharge after 6hr obs for asymptomatic (or only vomited 1-2x) AND ingestion <20mg/kg
- Admit to ICU if deferoxamine required
- Psychiatric evaluation if intentional ingestion
See Also
References
- ↑ 1.0 1.1 Robotham JL, Lietman PS: Acute iron poisoning. A review. Am J Dis Child 1980; 134:875-879.
- ↑ Robotham JL, Lietman PS. Acute iron poisoning. A review. Am J Dis Child 1980; 134:875-879.
- ↑ Aisen P et al. Iron toxicosis. Int Rev Exp Pathol 1990. 31:1-46.
- ↑ Lacouture PG et al. Emergency assessment of severity in iron overdose by clinical and laboratory methods. J Pediatr 1981; 99:89-91.
- ↑ Position paper: Whole bowel irrigation. J Toxicol Clin Toxicol 2004; 42:843-854.
- ↑ Mazzoleni G. et al. Yersinia enterocolitica infection with ileal perforation associated with iron overload and deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.
- ↑ Movassaghi N. et al. Comparison of exchange transfusion and deferoxamine in the treatment of acute iron poisoning. J Pediatr 1969; 75:604-608.