Rho(D) immune globulin: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[Vaginal bleeding in pregnancy (less than 20wks)|1st Trimester (<13weeks) Vaginal Bleeding]]=== | |||
* | *50 microgm IM | ||
** | **There is no harm in giving the standard 300 microgram dose, which is more readily available | ||
===[[Vaginal bleeding in pregnancy (greater than 20wks)|2nd & 3rd Trimester Vaginal Bleeding]]=== | |||
* | *300 microgm IM once and send Kleihauer-Betke test | ||
** | **Within 72hrs give additional 300 microgm/15 ml Rh-positive blood | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 07:18, 29 August 2015
General
- Type:
- Dosage Forms:
- Routes of Administration:
- Common Trade Names:
Adult Dosing
1st Trimester (<13weeks) Vaginal Bleeding
- 50 microgm IM
- There is no harm in giving the standard 300 microgram dose, which is more readily available
2nd & 3rd Trimester Vaginal Bleeding
- 300 microgm IM once and send Kleihauer-Betke test
- Within 72hrs give additional 300 microgm/15 ml Rh-positive blood
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Indications
- For fetal maternal hemorrhage
- Risk = >4-12wks
- Also given to Rh- male trauma patients who receive O+ blood to prevent future reaction with O+ transfusions[1]
Contraindications
- Allergy to class/drug
- Prior sensitization of mother
- Known Rh-negative father
- Known Rh-negative fetus (from cord blood)
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Comments
See Also
References
- ↑ Miraflor, E, et al. Emergency uncrossmatched transfusion effect on blood type alloantibodies. J Trauma. 2012; 72:48-53.