Chloroform toxicity: Difference between revisions
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*Solvent used in chemical and pharmaceutical industries | *Solvent used in chemical and pharmaceutical industries | ||
==Mechanism of Toxicity== | ===Mechanism of Toxicity=== | ||
*CNS depressant | *CNS depressant | ||
*Hepatic and renal toxicity via free radical formation | *Hepatic and renal toxicity via free radical formation | ||
| Line 10: | Line 10: | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
*Nausea | *[[Nausea]] | ||
*Vomiting | *[[Vomiting]] | ||
*Headache | *[[Headache]] | ||
*Confusion | *[[Confusion]] | ||
*Cardiac arrhythmia | *Cardiac [[arrhythmia]] | ||
*Coma | *Coma | ||
*Renal/Hepatic impairment | *Renal/Hepatic impairment | ||
==Diagnosis== | ==Differential Diagnosis== | ||
==Evaluation== | |||
*Based on clinical presentation | *Based on clinical presentation | ||
*Specific levels rarely available | *Specific levels rarely available | ||
== | ==Management== | ||
*Decontamination | *Decontamination | ||
*Avoid sympathomimetics like epinephrine which may trigger arrhythmia | *Avoid sympathomimetics like epinephrine which may trigger arrhythmia | ||
*N-acetylcysteine may minimize renal and hepatic toxicity | *[[N-acetylcysteine]] may minimize renal and hepatic toxicity | ||
==Disposition== | |||
==See Also== | ==See Also== | ||
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==References== | ==References== | ||
*Olson, K. Poisoning and Drug Overdose, 1999. | *Olson, K. Poisoning and Drug Overdose, 1999. | ||
[[Category:Toxicology]] | |||
Latest revision as of 21:38, 7 December 2017
Background
- Chloroform (Trichloromethane) is a chlorinated hydrocarbon
- Solvent used in chemical and pharmaceutical industries
Mechanism of Toxicity
- CNS depressant
- Hepatic and renal toxicity via free radical formation
- Arrhythmogenesis
- Carcinogenesis
Clinical Presentation
- Nausea
- Vomiting
- Headache
- Confusion
- Cardiac arrhythmia
- Coma
- Renal/Hepatic impairment
Differential Diagnosis
Evaluation
- Based on clinical presentation
- Specific levels rarely available
Management
- Decontamination
- Avoid sympathomimetics like epinephrine which may trigger arrhythmia
- N-acetylcysteine may minimize renal and hepatic toxicity
Disposition
See Also
External Links
References
- Olson, K. Poisoning and Drug Overdose, 1999.