Losartan: Difference between revisions
Bmurray990 (talk | contribs) |
|||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 8: | Line 8: | ||
===[[Hypertension]]=== | ===[[Hypertension]]=== | ||
*25-150mg PO daily | *25-150mg PO daily | ||
*Occasionally outpatient will prescribe BID dosing of losartan for potential continuous BP control (or [[lisinopril]]) | |||
**2020 large scale Kaiser study concluded no increased efficacy | |||
**There is potential for risk for AKI and hyperkalemia with lisinopril, but not losartan -- hypotension was not investigated<ref>Derington et al. Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety. PLoS One. 2020 Dec 3;15(12):e0243371. doi: 10.1371/journal.pone.0243371</ref> | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
| Line 47: | Line 50: | ||
==See Also== | ==See Also== | ||
*[[Hypertension]] | *[[Hypertension]] | ||
*[[Angiotensin II receptor antagonists]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Cardiology]] | |||
Latest revision as of 16:59, 22 April 2025
Administration
- Type: Antihypertensive, ARB
- Dosage Forms: Tablet; 25mg, 50mg, 100mg
- Routes of Administration: oral
- Common Trade Names: Cozaar
Adult Dosing
Hypertension
- 25-150mg PO daily
- Occasionally outpatient will prescribe BID dosing of losartan for potential continuous BP control (or lisinopril)
- 2020 large scale Kaiser study concluded no increased efficacy
- There is potential for risk for AKI and hyperkalemia with lisinopril, but not losartan -- hypotension was not investigated[1]
Pediatric Dosing
- 0.1 to 1.4 mg/kg daily
Special Populations
- Pregnancy Rating: D
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: starting dose 25mg daily
Contraindications
- Allergy to class/drug
- Concomitant use with aliskiren in diabetes
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 2-6 hours
- Metabolism: Hepatic;P450 CYP2C9 and CYP3A4
- Excretion: Fecal, renal
Mechanism of Action
- Reversible angiotensin II inhibitor
Comments
See Also
References
- ↑ Derington et al. Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety. PLoS One. 2020 Dec 3;15(12):e0243371. doi: 10.1371/journal.pone.0243371