Losartan

Administration

  • Type: Antihypertensive, ARB
  • Dosage Forms: Tablet; 25mg, 50mg, 100mg
  • Routes of Administration: oral
  • Common Trade Names: Cozaar

Adult Dosing

Hypertension

  • 25-150mg PO daily
  • Occasionally outpatient will prescribe BID dosing of losartan for potential continuous BP control (or lisinopril)
    • 2020 large scale Kaiser study concluded no increased efficacy
    • There is potential for risk for AKI and hyperkalemia with lisinopril, but not losartan -- hypotension was not investigated[1]

Pediatric Dosing

  • 0.1 to 1.4 mg/kg daily

Special Populations

Contraindications

  • Allergy to class/drug
  • Concomitant use with aliskiren in diabetes

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2-6 hours
  • Metabolism: Hepatic;P450 CYP2C9 and CYP3A4
  • Excretion: Fecal, renal

Mechanism of Action

  • Reversible angiotensin II inhibitor

Comments

See Also

References

  1. Derington et al. Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety. PLoS One. 2020 Dec 3;15(12):e0243371. doi: 10.1371/journal.pone.0243371