Leukopenia: Difference between revisions
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*Malignancy (infiltration in [[leukemia]], [[myeloproliferative disorders]] or bony metastases) | *Malignancy (infiltration in [[leukemia]], [[myeloproliferative disorders]] or bony metastases) | ||
*[[B12 deficiency|B12]] or [[folate deficiency]] | *[[B12 deficiency|B12]] or [[folate deficiency]] | ||
*Aplastic anemia]] | *[[Aplastic anemia]] | ||
*Infection | *Infection | ||
**[[Sepsis]] | **[[Sepsis]] | ||
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*Dependant on presentation | *Dependant on presentation | ||
==See Also== | ==See Also== | ||
*[[Pancytopenia]] | *[[Pancytopenia]] | ||
Latest revision as of 17:41, 15 August 2019
Background
- Low or absent white blood cell count
- Neutropenia is a subset
Clinical Features
- Immunosuppression--> increase risk of infection, including opportunistic pathogens
- +/- signs/symptoms of underlying disease
Differential Diagnosis
- Malignancy (infiltration in leukemia, myeloproliferative disorders or bony metastases)
- B12 or folate deficiency
- Aplastic anemia
- Infection
- Autoimmune disorders (e.g. SLE, Crohn's, RA)
- Drugs/tox
- Chemotherapeutics (antineoplastics, hydroxyurea, methotrexate)
- Radiation exposure
- Clozapine, chlorpromazine
- Phenytoin
- Sulfonamides, penicillin, cephalosporins, antiretrovirals
- Cimetidine
- Hypersplenism/splenic sequestration
- Miscellaneous
- Congenital, cyclic, "chronic benign neutropenia"
Evaluation
- Assess for infection
- Further evaluation dependant on presentation
Management
- Low threshold for empiric antimicrobials if any concern for infection
- May need only outpatient specialist referral if otherwise asymptomatic
Disposition
- Dependant on presentation