Hydrochlorothiazide: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: [[diuretic]] | ||
*Dosage Forms: | *Dosage Forms: 12.5mg, 25mg, 50mg | ||
*Common Trade Names: | *Common Trade Names: Microzide, Esidrix | ||
*Commonly abbreviated HCTZ | |||
*Must check chem 10 before prescribing in ED | |||
==Adult Dosing== | ==Adult Dosing== | ||
*[[Hypertension]]: 12.5 - 50 MG PO QDAY | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*< 6 months: 2-4mg/kg/day PO BID | |||
*6 mo - 2 yo: 1-2mg/kg/day PO BID, max 37.5mg/day | |||
*2 - 12 y/o: 1-2mg/kg/day PO qday-bid, max 100mg/day | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]:B | ||
*Lactation: | *Lactation: probably safe | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult: caution advised | ||
**Pediatric | **Pediatric: caution advised | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult: not defined | ||
**Pediatric | **Pediatric: not defined | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Anuria | |||
*neonatal jaundice | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*hypokalemia, severe | |||
*arrythmias | |||
*cholestatic jaundice | |||
*pancreatitis | |||
*steven johnson syndrome | |||
*renal failure | |||
*leukopenia | |||
===Common=== | ===Common=== | ||
*hypokalemia | |||
*hypochloremia | |||
*hyponatremia | |||
*hypomagnesium | |||
*hypercalcemia | |||
*hyperglycemia | |||
*hyperlipidemia | |||
*dizziness | |||
*diarrhea | |||
*headache | |||
*muscle cramps | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 5.6 - 14.8 hours | ||
*Metabolism: | *Metabolism: none | ||
*Excretion: | *Excretion: urine | ||
*Mechanism of Action: | *Mechanism of Action: inhibits distal convoluted tubule sodium and chloride resorption | ||
==See Also== | ==See Also== | ||
*[[Antihypertensives]] | |||
== | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] | |||
[[Category: | [[Category:Cardiology]] | ||
Latest revision as of 18:11, 22 October 2025
General
- Type: diuretic
- Dosage Forms: 12.5mg, 25mg, 50mg
- Common Trade Names: Microzide, Esidrix
- Commonly abbreviated HCTZ
- Must check chem 10 before prescribing in ED
Adult Dosing
- Hypertension: 12.5 - 50 MG PO QDAY
Pediatric Dosing
- < 6 months: 2-4mg/kg/day PO BID
- 6 mo - 2 yo: 1-2mg/kg/day PO BID, max 37.5mg/day
- 2 - 12 y/o: 1-2mg/kg/day PO qday-bid, max 100mg/day
Special Populations
- Pregnancy Rating:B
- Lactation: probably safe
- Renal Dosing
- Adult: caution advised
- Pediatric: caution advised
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Anuria
- neonatal jaundice
Adverse Reactions
Serious
- hypokalemia, severe
- arrythmias
- cholestatic jaundice
- pancreatitis
- steven johnson syndrome
- renal failure
- leukopenia
Common
- hypokalemia
- hypochloremia
- hyponatremia
- hypomagnesium
- hypercalcemia
- hyperglycemia
- hyperlipidemia
- dizziness
- diarrhea
- headache
- muscle cramps
Pharmacology
- Half-life: 5.6 - 14.8 hours
- Metabolism: none
- Excretion: urine
- Mechanism of Action: inhibits distal convoluted tubule sodium and chloride resorption