Enalaprilat: Difference between revisions
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Latest revision as of 21:56, 20 March 2026
Administration
- Type: ACE inhibitor
- Dosage Forms:
- Routes of Administration: IV
- Common Trade Names: Vasotec
Adult Dosing
- 1.25-5mg IV q6h
- 0.625mg IV initially, with repeated dose of 0.625mg if inadequate response for the following patients:
- CrCl <30
- Severe volume or salt depletion, recent HD, or concomitant diuretic use
- CHF
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk minimal
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
- Angioedema history (ACEi-induced, hereditary, or idiopathic)
Adverse Reactions
Serious
- Myocardial infarction
- Liver failure
- Angioedema
Common
- Hyperkalemia
- Nausea
- Headache
Pharmacology
- Half-life: ~11h
- Metabolism:
- Excretion: Renal. Dialyzable
Mechanism of Action
- Inhibits angiotensin converting enzyme, blocking conversion of angiotensin I to angiotensin II.
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Congestive heart failure | 0.004 mg/kg IV bolus or 1 mg IV drip over 2 hours | ACE inhibitor for afterload reduction | IV | Adult |
| Hypertensive emergency | 0.625-1.25 mg IV q6 hr | ACE inhibitor | IV | Adult |