Enalaprilat

Administration

  • Type: ACE inhibitor
  • Dosage Forms:
  • Routes of Administration: IV
  • Common Trade Names: Vasotec

Adult Dosing

  • 1.25-5mg IV q6h
  • 0.625mg IV initially, with repeated dose of 0.625mg if inadequate response for the following patients:
    • CrCl <30
    • Severe volume or salt depletion, recent HD, or concomitant diuretic use
    • CHF

Pediatric Dosing

Safety/efficacy not established

Special Populations

Hepatic Dosing

  • Adult:
  • Pediatric:

Contraindications

  • Allergy to class/drug
  • Angioedema history (ACEi-induced, hereditary, or idiopathic)

Adverse Reactions

Serious

  • Myocardial infarction
  • Liver failure
  • Angioedema

Common

Pharmacology

  • Half-life: ~11h
  • Metabolism:
  • Excretion: Renal. Dialyzable

Mechanism of Action

  • Inhibits angiotensin converting enzyme, blocking conversion of angiotensin I to angiotensin II.

Comments

See Also

References