Zollinger-Ellison syndrome: Difference between revisions
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==Background== | ==Background== | ||
* | *Also known as "S-E syndrome" | ||
*gastric neuroendocrine malignancy results in hypersecretion of hydrochloric acid by parietal cells | *gastric neuroendocrine malignancy results in hypersecretion of hydrochloric acid by parietal cells | ||
*Associated with peptic ulcers and diarrhea | *Associated with peptic ulcers and diarrhea | ||
Revision as of 21:02, 31 August 2022
Background
- Also known as "S-E syndrome"
- gastric neuroendocrine malignancy results in hypersecretion of hydrochloric acid by parietal cells
- Associated with peptic ulcers and diarrhea
- 60% malignant, only 20% resectable; 25% of gastrinoma patients have multiple endocrine neoplasia type I; >80% of gastrinomas found in gastrinoma triangle.
Clinical Features
- Hematemesis
- Chronic diarrhea
- Postprandial abdominal pain
- Nausea
- Wheezes on auscultation
- Evidence of malnourishment and decreased oral intake