Idiopathic pulmonary fibrosis: Difference between revisions
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==Background== | ==Background== | ||
*Median survival time 3 yrs after diagnosis | |||
*Prevalence about 10-20 cases per 100,000 people | |||
*Acute exacerbations carry mortality up to 80% | |||
*60% die from idiopathic pulmonary fibrosis, others die from: | |||
**VTE | |||
**Cardiovascular (ACS, CHF) | |||
**Infection | |||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 10:06, 13 April 2016
Background
- Median survival time 3 yrs after diagnosis
- Prevalence about 10-20 cases per 100,000 people
- Acute exacerbations carry mortality up to 80%
- 60% die from idiopathic pulmonary fibrosis, others die from:
- VTE
- Cardiovascular (ACS, CHF)
- Infection
Clinical Features
DDx
Pulmonary Fibrosis
- Interstitial pneumonias (acute, lymphocytic)
- Lung malignancy
- Aspiration pneumonia or pneumonitis
- Bacterial, viral, or fungal pneumonia
- Cryptogenic organizing pneumonia
- Interstitial lung disease associated with collagen vascular disease
- Drug-induced pulmonary toxicity (amiodarone, bleomycin, amphotericin B, carbamazepine, etc.)
- Eosinophilic granuloma (Histiocytosis X)
- Radiation pneumonitis
- Sarcoidosis
- Pneumoconiosis (Workplace exposure)
- Asbestosis
- Berylliosis
- Chemical worker's lung
- Coal worker's pneumoconiosis
- Silicosis
See Also
Sources
- Collard HR et al. Acute Exacerbations of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2007 Oct 1; 176(7): 636–643.
- Ryerson CJ et al. Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm. Eur Respir J. 2015 Aug;46(2):512-20.
- Juarez MM et al. Acute exacerbation of idiopathic pulmonary fibrosis—a review of current and novel pharmacotherapies. J Thorac Dis. 2015 Mar; 7(3): 499–519.