Dopamine: Difference between revisions
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==General== | ==General== | ||
*Type: [[Vasopressors]] | *Type: [[Vasopressors]] | ||
*Dosage Forms: | *Dosage Forms: IV | ||
*Common Trade Names: | *Common Trade Names: Intropin | ||
==Adult Dosing== | ==Adult Dosing== | ||
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: Class C | ||
*Lactation: | *Lactation: | ||
*Renal Dosing | *Renal Dosing | ||
Revision as of 17:54, 30 September 2016
General
- Type: Vasopressors
- Dosage Forms: IV
- Common Trade Names: Intropin
Adult Dosing
Dosing
- Low dose:
- 1-5 mcg/kg/min - Vasodilation (renal, mesenteric, coronary)
- 5-10 mcg/kg/min - predominant β1
- High dose: 10-20 mcg/kg/min - predominant α1
- Titrate to clinical effect
- Use lowest dose possible (prevent tachyphylaxis)
- May use in peripheral IV temporarily
- Avoid using in same line as alkaline infusions
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating: Class C
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- Tachyarrhythmias
Adverse Reactions
- Low doses:
- Hypotension
- High doses:
- Hypertension, ectopic beats
- Tissue necrosis (if extravasates)
- If occurs use phentolamine 5-10mg in affected area
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- Low dose: DA, β1
- High dose: DA, α1 >> β1
Relative Effects
- Low dose: Natriuresis, ↑↑HR, ↑↑SV
- High dose: ↑SVR and ↑SV
Notes
Indications
- Hypotension caused by:
- Septic shock
- MI
- Trauma/spinal shock
- Heart failure