Cephalosporins: Difference between revisions
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==1st Generation== | |||
* Cefazolin, [[Cephalexin]] | |||
** Skin and soft tissue infections (why is agent of choice before gen sx) | |||
* [[Ceftriaxone_Cross-reactivity|Cross-reactivity of PCN]] allergy <10% | |||
==2nd Generation== | |||
* Cefuroxime | |||
** Intestinal anaerobes (why is agent of choice for colorectal sx) | |||
** Largely displaced by 3rd gen agents | |||
==3rd Generation== | |||
* | *[[Ceftriaxone]], Ceftazidime, Cefixime | ||
** Drug of choice for serious infections due to: | |||
*** Klebsiella | |||
*** Enterobacter | |||
*** Proteus | |||
*** Haemophilus | |||
** | ** [[Gonorrhea]] | ||
** | ** [[Lyme Disease]] | ||
** | ** [[Meningitis]] (+ vanc and ampicillin) | ||
** Pseudomonas meningitis (+ AG) | |||
==4th Generation== | |||
* Cefepime | |||
** Resistant, nosocomial infections | |||
{{Template:Clinically Utilized Antibiotics}} | {{Template:Clinically Utilized Antibiotics}} | ||
Revision as of 04:06, 20 February 2014
1st Generation
- Cefazolin, Cephalexin
- Skin and soft tissue infections (why is agent of choice before gen sx)
- Cross-reactivity of PCN allergy <10%
2nd Generation
- Cefuroxime
- Intestinal anaerobes (why is agent of choice for colorectal sx)
- Largely displaced by 3rd gen agents
3rd Generation
- Ceftriaxone, Ceftazidime, Cefixime
- Drug of choice for serious infections due to:
- Klebsiella
- Enterobacter
- Proteus
- Haemophilus
- Gonorrhea
- Lyme Disease
- Meningitis (+ vanc and ampicillin)
- Pseudomonas meningitis (+ AG)
- Drug of choice for serious infections due to:
4th Generation
- Cefepime
- Resistant, nosocomial infections
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See Also
Source
Goodman & Gilman's Pharmacology