Minocycline
General
- Type: tetracycline
- Dosage Forms: IV, PO
- Common Trade Names:
Adult Dosing
- IV or PO: 200 mg initial dose, then 100 mg q12h.
Pediatric Dosing
- Avoided in children < 8 d/t calcium deposition in teeth
- Children >8 years: PO, IV: 4 mg/kg/dose for 1 dose; Then 2 mg/kg/dose every 12 hours
Special Populations
- Pregnancy Rating: D
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
References
- ↑ Sanford Guide to Antimicrobial Therapy 2014