Cephalosporins: Difference between revisions
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==1st Generation== | ==1st Generation== | ||
** Skin and soft tissue infections (why is agent of choice before gen sx) | ** Skin and soft tissue infections (why is agent of choice before gen sx) | ||
* [[Ceftriaxone_Cross-reactivity|Cross-reactivity of PCN]] allergy <10% | * [[Ceftriaxone_Cross-reactivity|Cross-reactivity of PCN]] allergy <10% | ||
==2nd Generation== | ==2nd Generation== | ||
** Intestinal anaerobes (why is agent of choice for colorectal sx) | ** Intestinal anaerobes (why is agent of choice for colorectal sx) | ||
** Largely displaced by 3rd gen agents | ** Largely displaced by 3rd gen agents | ||
==3rd Generation== | ==3rd Generation== | ||
** Drug of choice for serious infections due to: | ** Drug of choice for serious infections due to: | ||
*** Klebsiella | *** Klebsiella | ||
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** Pseudomonas meningitis (+ AG) | ** Pseudomonas meningitis (+ AG) | ||
==4th Generation== | ==4th Generation== | ||
** Resistant, nosocomial infections | ** Resistant, nosocomial infections | ||
Revision as of 20:20, 26 March 2014
1st Generation
- Skin and soft tissue infections (why is agent of choice before gen sx)
- Cross-reactivity of PCN allergy <10%
2nd Generation
- Intestinal anaerobes (why is agent of choice for colorectal sx)
- Largely displaced by 3rd gen agents
3rd Generation
- Drug of choice for serious infections due to:
- Klebsiella
- Enterobacter
- Proteus
- Haemophilus
- Gonorrhea
- Lyme Disease
- Meningitis (+ vanc and ampicillin)
- Pseudomonas meningitis (+ AG)
- Drug of choice for serious infections due to:
4th Generation
- Resistant, nosocomial infections
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See Also
Source
Goodman & Gilman's Pharmacology