Yohimbine toxicity: Difference between revisions
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Revision as of 23:05, 20 October 2018
Background
Indole alkylamine from West African Yohimbine tree (Corynanthe yohimbe)
α2-adrenergic antagonist with cholinergic activity
Commonly used for treating erectile dysfunction. Also, for other uses (eg, postural hypotension); marketed as athletic performance enhancers, dieting agent.
Can be obtained via prescription.
Clinical Features
- Tachycardia
- Hypertension
- Mydriasis
- Nausea, vomiting, salivation
- Anxiety
- Large ingestions may cause mania, bronchospasm, lupus-like syndrome
Differential Diagnosis
Management
Symptomatic patients:
Benzodiazepines for agitation/anxiety/sympathomimetic effects
Avoid β-Adrenergic antagonists - may lead to unopposed α1-adrenergic activity → ↑ hypertension
See Also
External Links
References
Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.