Yohimbine toxicity

Background

  • Indole alkylamine from West African Yohimbine tree (Corynanthe yohimbe)
  • α2-adrenergic antagonist with cholinergic activity[1]
  • Commonly used for treating erectile dysfunction. Also, for other uses (eg, postural hypotension); marketed as athletic performance enhancers, dieting agent.
  • Can be obtained via prescription.

Clinical Features[2]

Differential Diagnosis

Evaluation

Management

Avoid β-Adrenergic antagonists - may lead to unopposed α1-adrenergic activity → ↑ hypertension

  • Symptomatic patients:
    • Benzodiazepines for agitation/anxiety/sympathomimetic effects

Disposition

See Also

External Links

References

  1. Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.
  2. Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.

Authors:

Ross Donaldson, ych