Acanthosis nigricans: Difference between revisions
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**Rapid appearance of lesions | **Rapid appearance of lesions | ||
[[File:acanthosis-nigricans associatd with gastric Ca.jpg|thumbnail]] | [[File:acanthosis-nigricans associatd with gastric Ca.jpg|thumbnail]] | ||
**Extensive involvement | |||
**Older adult | |||
**Unexplained weight loss | |||
**Lesions in atypical sites such as palms/soles, mucous membranes | |||
==See Also== | ==See Also== | ||
Revision as of 02:06, 22 October 2018
Background
- Multiple forms, but malignant acanthosis nigricans is most important
- Clinically indistinguishable from benign form
Clinical Features
- Hyperpigmented, velvety
- Plaques
- Most commonly intertriginous areas, posterior neck
- May have concurrent acrochordons, skin tags
Malignant Acanthosis Nigricans[1]
- Associated with other dermal manifestations of internal cancers
- Most commonly associated with colonic adenocarcinoma, gastric cancer
- Red flags:
- Up to 50% of malignant acanthosis nigricans have oral involvement
- Rapid appearance of lesions
- Extensive involvement
- Older adult
- Unexplained weight loss
- Lesions in atypical sites such as palms/soles, mucous membranes
See Also
References
- ↑ Miller JH et al. Acanthosis Nigricans Clinical Presentation. eMedicine. Dec 3, 2015. http://emedicine.medscape.com/article/1102488-clinical#showall.