Metaproterenol: Difference between revisions
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==Special Populations== | ==Special Populations== | ||
*[[Drug pregnancy categories|Pregnancy Rating]]: May interfere with uterine contractility | *[[Drug pregnancy categories|Pregnancy Rating]]: C. Adverse events observed in animal studies. May interfere with uterine contractility if administered during labor | ||
*Lactation risk: Caution advised | *Lactation risk: Caution advised | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
Revision as of 21:32, 26 January 2019
Administration
- Type: Beta-2 agonist
- Dosage Forms: TAB: 10mg, 20mg; SOL: 10mg per 5mL
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
Asthma
- 20mg PO tid-qid
Pediatric Dosing
Asthma
- 6-9 yo or <60lb
- 10mg PO tid-qid
- >9yo or >60lb
- 20mg PO tid-qid
Special Populations
- Pregnancy Rating: C. Adverse events observed in animal studies. May interfere with uterine contractility if administered during labor
- Lactation risk: Caution advised
Renal Dosing
- Adult: No adjustment
- Pediatric: No adjusment
Hepatic Dosing
- Adult: No adjustment
- Pediatric: No adjustment
Contraindications
- Allergy to class/drug
- Tachyarrhythmia
Adverse Reactions
Serious
- Bronchoconstriction, paradoxical
- Hypersensitivity rxn
- Hypertension, hypotension
- Angina
- Cardiac arrest
- Arrhythmia
- Hypokalemia
- Hyperglycemia
Common
- Nervousness
- Tachycardia
- Tremor
- Headache
- Palpitations
- Nausea, dizziness
- Insomnia
Pharmacology
- Half-life: 6h
- Metabolism: Liver, GI tract
- Excretion: Urine
Mechanism of Action
- Selectively stimulates beta-2 adrenergic receptors, relaxing airway smooth muscle