Ebola virus disease: Difference between revisions
| Line 6: | Line 6: | ||
*Unknown reservoir with most likely being bats | *Unknown reservoir with most likely being bats | ||
===2014 | ===2014 Country Details<ref>CDC Website, accessed 10/15/2014</ref>=== | ||
* | *Widespread Transmission | ||
* | **Guinea | ||
** | **Liberia | ||
***Port Harcourt | **Sierra Leone | ||
*** | *Localized Transmission | ||
***Dakar, Senegal | **Nigeria^ (Port Harcourt and Lagos) | ||
**Spain^^ (Madrid) | |||
**United States^^ (Dallas, TX) | |||
*Travel-associated | |||
**Senegal^^ (Dakar) | |||
^Persons who entered Nigeria (on or after September 30, 2014) and Senegal (on or after September 20, 2014) are NOT at risk for exposure to Ebola. | |||
^^should NOT be considered to be at risk for exposure to Ebola. | |||
===2014 Domestic Outbreak Details=== | ===2014 Domestic Outbreak Details=== | ||
Revision as of 20:53, 16 October 2014
Background
- An RNA based virus from the Filovirus Family with 5 species mainly originating from Africa.
- Outbreaks in Gabon, Africa occured in 1996 and in July, 2014[1]
- Viral hemorrhagic fever
- Unknown reservoir with most likely being bats
2014 Country Details[2]
- Widespread Transmission
- Guinea
- Liberia
- Sierra Leone
- Localized Transmission
- Nigeria^ (Port Harcourt and Lagos)
- Spain^^ (Madrid)
- United States^^ (Dallas, TX)
- Travel-associated
- Senegal^^ (Dakar)
^Persons who entered Nigeria (on or after September 30, 2014) and Senegal (on or after September 20, 2014) are NOT at risk for exposure to Ebola.
^^should NOT be considered to be at risk for exposure to Ebola.
2014 Domestic Outbreak Details
- September 20
- Index case arrives in Dallas from Liberia
- September 25 & 28
- Index case visits hospital
- September 30
- first U.S. diagnosis of Ebola (index patient)
- October 8
- Index patient dies
- CDC implements enhanced entry screening at five U.S. airports
- October 10
- A healthcare worker who cared for index patient tests positive
- October 14
- A second healthcare worker tests positive for Ebola
- CDC establishes a dedicated response team for confirmed cases
Communicable Transmission
- Via blood and body fluids (urine, saliva, semen, feces, vomit) in contact with mucous membranes or via instruments such as needles[3]
Clinical Features[4]
- Severe, often fatal (40-65%) hemorrhagic fever
- Incubation period: 2-21 days (most commonly ~11 days)
- Common symptoms:
- fever (87.1%)
- fatigue (76.4%)
- Loss of appetite (64.5%)
- vomiting (67.6%)
- diarrhea (65.6%)
- headache (53.4%)
- abdominal pain (44.3%)
- Hemorrhagic symptoms (<43%)
Differential Diagnosis
Fever in traveler
- Normal causes of acute fever!
- Malaria
- Dengue
- Leptospirosis
- Typhoid fever
- Typhus
- Viral hemorrhagic fevers
- Chikungunya
- Yellow fever
- Rift valley fever
- Q fever
- Amebiasis
- Zika virus
Workup
- For travelers returning from countries with active Ebola follow theCDC Algorithm for Evaluation of the Returned Traveler
Persons under Investigation (PUI)
- Obtain a travel history for all persons presenting with fever
- Consider Ebola in any person who presents within 21 days of traveling to an epidemic area
- During evaluation isolate with standard, contact, and droplet precautions
- Immediately to the PUIs to local health authorities or CDD
- Los Angeles repots to Acute Communicable Disease Control Program (ACDC) at 213-240-7941 (nights/weekends: 213-974-1234)
- Special diagnostic testing requires consultation
Diagnostics
A few days after infectious symptoms begin, ELISA IgM, PCR or virus isolation are possible. Later in the disease or during recovery, IgM or IgG can be tested.
Management
- Isolation precautions: standard, contact and droplet[5]
- Isolate in a single room with the door closed
- Limit entry and maintain a log of people who enter the room
- Use standard, contact, and droplet precautions
- Test and treat for other possible causes of Fever in Travelers while evaluating for Ebola
- CDC has guidance for safe specimen handling
- Supportive care
- Currently no non-experimental medications directed at the Ebola virus, although newer medications are under evaluation
Disposition
Admit, isolation, possible ICU for serologic results and clinical observation/supportive care.
See Also
External Links
http://www.cdc.gov/vhf/ebola/index.html
Sources
- ↑ Ebola Virus Disease, West Africa http://www.afro.who.int/en/clusters-a-programmes/dpc/epidemic-a-pandemic-alert-and-response/outbreak-news/4233-ebola-virus-disease-west-africa-25-july-2014.html.
- ↑ CDC Website, accessed 10/15/2014
- ↑ Peters CJ. Chapter 197. Ebola and Marburg Viruses. Harrison’s Principles of Internal Medicine, 18e. 2012
- ↑ Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward Projections. N Engl J Med 2014;371:1481-95
- ↑ Cite error: Invalid
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