Levamisole toxicity: Difference between revisions
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==Background== | ==Background== | ||
*an antihelminthic and immunomodulator | *an antihelminthic and immunomodulator that has been withdrawn from the U.S. and Canadian markets, due to the risk of serious side effects | ||
*Increasingly used as a cutting agent in cocaine sold around the globe | *Increasingly used as a cutting agent in cocaine sold around the globe | ||
*Results in Levamisole induced necrosis syndrome<ref>http://www.ncbi.nlm.nih.gov/pubmed/20668440</ref> | *Results in Levamisole induced necrosis syndrome<ref>http://www.ncbi.nlm.nih.gov/pubmed/20668440</ref> | ||
Revision as of 08:54, 29 October 2014
Background
- an antihelminthic and immunomodulator that has been withdrawn from the U.S. and Canadian markets, due to the risk of serious side effects
- Increasingly used as a cutting agent in cocaine sold around the globe
- Results in Levamisole induced necrosis syndrome[1]
Clinical Features
- agranulocytosis
- neutropenia
- levamisole induced necrosis syndrome
- Necrotic patches anywhere on skin (especially ears and legs)
Differential Diagnosis
Workup
- CBC
Management
- Neutropenia
- Consider neupogen
- Observation for neutropenic fever
- Necrosis
- Aggressive supportive care
- Burn care if significant necrosis
Disposition
Admission