Histoplasmosis: Difference between revisions
Vincent Chan (talk | contribs) |
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*Blastomycosis | *Blastomycosis | ||
*Carcinoid Lung Tumors | *Carcinoid Lung Tumors | ||
* | *[[Chlamydophila psittaci]] | ||
*Coccidioidomycosis | *[[Coccidioidomycosis]] | ||
*Legionella pneumonias | *[[Legionella]] pneumonias | ||
*Lung Cancer, Small Cell | *Lung Cancer, Small Cell | ||
*Lymphoma, Mediastinal | *Lymphoma, Mediastinal | ||
*Mediastinal Cysts | *Mediastinal Cysts | ||
*Mycoplasma Infections | *[[Lung Abscess]] | ||
*[[Mycoplasma pneumonia|Mycoplasma Infections]] | |||
*Pancoast Syndrome | *Pancoast Syndrome | ||
*Pneumococcal Infections | *Pneumococcal Infections | ||
*Pneumocystis Carinii Pneumonia | *Pneumocystis Carinii Pneumonia | ||
* | *[[Aspiration Pneumonia]] | ||
*[[Pneumonia]] | |||
*Pneumonia | *[[Sarcoidosis]] | ||
*[[Tuberculosis]] | |||
*Sarcoidosis | |||
*Tuberculosis | |||
==Workup== | ==Workup== | ||
*CBC (mild anemia in chronic disease) | *CBC (mild anemia in chronic disease) | ||
Revision as of 14:55, 1 December 2014
Background
- Fungal infection caused by Histoplasma capsulatum[1]
- Endemic to the Ohio, Missouri, and Mississippi River valleys in the United States[2]
Clinical Features
Acute Pulmonary Histoplasmosis
- 90% asymptomatic, and usually self-limited
- Fever/chills
- Headache
- Malaise
- Myalgias
- Abdominal pain
- Joint pains
- Dyspnea
- Cough
- Hemoptysis
- Hilar/mediastinal lymphadenopathy
Chronic Pulmonary Histoplasmosis
- Mostly older patients with underlying lung disease
- Cough
- Weight loss
- Fever
- Malaise
- Sometimes hemoptysis, sputum production, dyspnea
- CXR may show:
- Upper lobe infiltrates
- Fibrosis, scarring
- Cavitations
Progressive Disseminated Histoplasmosis
- Seen in immunocompromised patients
- Acute form: fever, cough, weight loss, malaise, dyspnea, +/-CNS involvement
- Subacute form: wide variety of symptoms depending on affected organ system
- Chronic form: constitutional sx
Mediastinitis
- Enlarged lymph nodes undergo necrosis
- This leads to granulomatous mediastinitis
Differential Diagnosis
- Aspergillosis
- Blastomycosis
- Carcinoid Lung Tumors
- Chlamydophila psittaci
- Coccidioidomycosis
- Legionella pneumonias
- Lung Cancer, Small Cell
- Lymphoma, Mediastinal
- Mediastinal Cysts
- Lung Abscess
- Mycoplasma Infections
- Pancoast Syndrome
- Pneumococcal Infections
- Pneumocystis Carinii Pneumonia
- Aspiration Pneumonia
- Pneumonia
- Sarcoidosis
- Tuberculosis
Workup
- CBC (mild anemia in chronic disease)
- Alkaline phosphatase (elevated in disseminated and chronic disease)
- LDH (elevated in AIDS patients with disseminated disease)
- Sputum cultures
- Blood cultures
- Antibody testing
- Serum/urine antigen testing
- CXR
- Further imaging if concerned for specific organ involvement in disseminated disease (head CT, abdominal CT)
Treatment
Acute Pulmonary Histoplasmosis
- Do not treat if asymptomatic
- Itraconazole x 6-12 weeks
- Severe disease: Amphotericin B x 1 week then Itraconazole x 1 year
Chronic Pulmonary Histoplasmosis
- Itraconazole x 1 year
Progressive Disseminated Histoplasmosis
- See above medical therapy
- Surgical intervention may be needed for some end organ involvement