Template:Botulism treatment: Difference between revisions
(removed region-specific info)
Line 1: Line 1:
If suspect possible bioterrorism, contact CDC +1-770-488-7100
===Supportive Care===
===Supportive Care===
*Early ventilatory support
*Early ventilatory support
Line 6: Line 5:
**Early wound debreedment with surgical consult.
**Early wound debreedment with surgical consult.
**Also exclude [[Necrotizing fasciitis]] and coverage with same broad antibiotic coverage
**Also exclude [[Necrotizing fasciitis]] and coverage with same broad antibiotic coverage
===Foodborne Botulism===
===Foodborne Botulism===
*Equine Serum Botulism Antitoxin
*Equine Serum Botulism Antitoxin
**only for patients > 1yo
**only for patients > 1yo
*Antitoxin obtained through department of health / CDC. Hotline in LA: (888) 397-3993<ref name="LA DOH">http://www.publichealth.lacounty.gov/acd/Cdrs.htm</ref>
*Antitoxin obtained through CDC or local Department of Health.


===Infant Botulism (<1yo)===
===Infant Botulism (<1yo)===
*Human-based Botulism IG 100mg/kg IV x 1 dose (BabyBIG)
*Human-based Botulism IG 100mg/kg IV x 1 dose (BabyBIG)
**infusion divided into 25mg/kg/hr IV x 15 min FOLLOWED by 50mg/kg/hr if no allergic reactions
**infusion divided into 25mg/kg/hr IV x 15 min followed by 50mg/kg/hr if no allergic reactions
**Stop infusion after total of 100mg/kg infused
**Stop infusion after total of 100mg/kg infused
*To report suspected cases and obtain BabyBIG: California DHS Infant Botulism Treatment and Prevention Program: (510) 231-7600<ref>http://www.infantbotulism.org/</ref>
*BabyBIG obtained through CDC or local Department of Health


===Inhalational Botulism===
===Inhalational Botulism===
*Equine Serum Botulism Antitoxin
*Equine Serum Botulism Antitoxin
**only for patients > 1yo
**only for patients > 1yo
*Antitoxin obtained through dept of health / CDC. Hotline in LA: (888) 397-3993<ref name="LA DOH"/>
*Antitoxin obtained through CDC or local Department of Health


===Wound Botulism===
===Wound Botulism===
*Individualize therapy with ID consultant
*Individualize therapy with ID consultant
*Broad antibiotic coverage same as for [[Necrotizing fasciitis]] while awaiting wound cultures
*Broad antibiotic coverage same as for [[Necrotizing fasciitis]] while awaiting wound cultures

Revision as of 06:36, 18 August 2015

Supportive Care

  • Early ventilatory support
    • Consider intubation when vital capacity <30% predicted or <12cc/kg
  • Wound Managment
    • Early wound debreedment with surgical consult.
    • Also exclude Necrotizing fasciitis and coverage with same broad antibiotic coverage

Foodborne Botulism

  • Equine Serum Botulism Antitoxin
    • only for patients > 1yo
  • Antitoxin obtained through CDC or local Department of Health.

Infant Botulism (<1yo)

  • Human-based Botulism IG 100mg/kg IV x 1 dose (BabyBIG)
    • infusion divided into 25mg/kg/hr IV x 15 min followed by 50mg/kg/hr if no allergic reactions
    • Stop infusion after total of 100mg/kg infused
  • BabyBIG obtained through CDC or local Department of Health

Inhalational Botulism

  • Equine Serum Botulism Antitoxin
    • only for patients > 1yo
  • Antitoxin obtained through CDC or local Department of Health

Wound Botulism

  • Individualize therapy with ID consultant
  • Broad antibiotic coverage same as for Necrotizing fasciitis while awaiting wound cultures
Retrieved from "https://www.wikem.org/w/index.php?title=Template:Botulism_treatment&oldid=44054"