Typhus: Difference between revisions
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*Usually clinically | *Usually clinically | ||
Revision as of 06:26, 26 July 2016
Background
- Not to be confused with typhoid fever, a distinct disease caused by a different genera of bacteria
- Any of several similar diseases caused by Rickettsia bacteria (e.g. Rickettsia prowazekii, )
Clinical Features
- Fever, headache, myalgias[1]
- Transmitted by arthropods/ ticks
- Painless eschar at inoculation site imp clue
- Camping, hiking in grassy/ scrub area
- Regional lymphadenopathy, rash
Differential Diagnosis
Fever in traveler
- Normal causes of acute fever!
- Malaria
- Dengue
- Leptospirosis
- Typhoid fever
- Typhus
- Viral hemorrhagic fevers
- Chikungunya
- Yellow fever
- Rift valley fever
- Q fever
- Amebiasis
- Zika virus
Evaluation
- leukopenia, thrombocytopenia
- Usually clinically
Management
- Tetracycline
- Chloramphenicol may be an alternative, though associated with higher morbidity
- Confirm serologically, not useful in acute phase