Ketoconazole
Administration
- Type: Antifungal
- Dosage Forms:
- Routes of Administration: PO, topical
- Common Trade Names:
Adult Dosing
- Fungal infxns
- 200-400 mg PO qday
- Prostate cancer
- 400 mg PO q8h
Pediatric Dosing
- Fungal infxns (2 years and up)
- 3.3-6.6 mg/kg PO qday
Special Populations
Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
Hepatic Dosing
- Adult: contraindicated in liver disease
- Pediatric: contraindicated in liver disease
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hepatotoxicity
- Adrenal insufficiency
- Hypersensitivity reaction
- Anaphylaxis
- Thrombocytopenia
- Leukopenia
- Hemolytic Anemia
Common
- Nausea
- Abdominal Pain
- Dizziness
- Diarrhea
- Headache
- Pruritis
- Lethargy
- Gynecomastia
Pharmacology
- Half-life: 8 h
- Metabolism: Liver (CYP450)
- Excretion: feces > urine
Mechanism of Action
- Inhibits synthesis of cell membrane ergosterol