Chlorate toxicity

Background

• Potassium Chlorate, Barium Chlorate, and Sodium Chlorate are still in use today
• Fireworks, match heads, and weed killers

Mechanism of Toxicity

• Oxidizers and attackers of sulfhydryl groups
• Cause methemoglobin formation

Clinical Presentation

• Abdominal pain
• Vomiting
• Diarrhea
• Methemoglobinemia
• Coagulopathy

Evaluation

• Based on clinical history and presence of methemoglobinemia
• No specific levels are available

Management

• Activated charcoal IS recommended
• Methylene blue for methemoglobinemia (1-2 mg/kg of 1% solution)
• Sodium thiosulfate IV may inactivate chlorate ions (anecdotal)
• Hemodialysis
• Supportive Care

References

Olson, K. Poisoning and Drug Overdose, 1999.