Pantoprazole

General

• Type: Proton-pump inhibitor
• Dosage Forms:
• Common Trade Names: Protonix, Somac, Forppi, Pantoloc, Pantozol, Pantomed, Zurcal, Zentro, Pan, Controloc, Tecta

Adult Dosing

Upper gastrointestinal bleeding

• 80mg x 1; then 8mg/hr

Special Populations

• Pregnancy Rating:
• Lactation:
  • Pantoprazole is present in breast milk
• Renal Dosing
  • Adult
    • No adjustment necessary
  • Pediatric
    • Not defined
• Hepatic Dosing
  • Adult
    • No adjustment necessary
  • Pediatric
    • Not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• anaphylaxis
• SJS/TEN
• Renal impairment
• pancreatitis
• hepatic impairment

Common

• Headache
• abdominal pain
• nausea/vomiting/diarrhea
• AST/ALT elevation

Pharmacology

• Half-life: 1 hour
• Metabolism: Hepatic - CYP450
• Excretion: Urine/Feces
• Mechanism of Action: inhibits gastric parietal cell H+/K+ ATPase