Template:Meningitis Antibiotics

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Guidelines:[1]

Age 18-50y
  1. Ceftriaxone 2gm IV q12hr + vancomycin 15mg/kg q8-12hr
  2. (vancomycin is for resistant pneumococcus)
Age >50y
  1. Ceftriaxone 2gm IV q12hr + vancomycin 15mg/kg q8-12hr + ampicillin 2gm IV q4h
CSF leak with closed head trauma
  1. Ceftriaxone 2gm IV q12hr + vancomycin 15mg/kg q8-12hr
Penetrating head injury (or recent surgery)
  1. (Ceftazidime 2gm IV q8hr or cefepime or meropenem) + vanco 25 milligrams/kg load
Meningitis due to Sinusitis
  1. Ceftriaxone + Metronidazole
Meningitis with severe PCN allergy
  1. chloramphenicol 1g IV q6h + vancomycin 15mg/kg q8-12hr
  1. ↑ van de Beek D. et al. Advances in treatment of bacterial meningitis. Lancet. Nov 10 2012;380(9854):1693-702
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