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General
- Type: Anti-Staphylococcal Penicillin
- Dosage Forms: IM; IV
- Common Trade Names:
Adult Dosing
General
- Mild-to-moderate infection
- 250-500 mg IM/IV q4-6 hours
- Severe infection
- 2g IV q4 hours
- Examples: brain abscess, bursitis, erysipelas, mastitis, mastoiditis, osteomyelitis, perinephric abscess, pneumonia, pyomyositis, Scalded Skin Syndrome, Toxic Shock Syndrome
Pediatric Dosing
General
- Mild-to-moderate
- 50 mg/kg/day IM/IV divided q6 hours
- First Dose: 12.5 mg/kg IM/IV x 1
- Max: 4 g/day
- Severe
- 100 mg/kg/day IM/IV divided q4-6 hours
- First Dose: 16.6-25 mg/kg IM/IV x 1
- Max: 12 g/day
- 150-200 mg/kg/day divided q6-8 hours
- First Dose: 37.5-66.6 mg/kg IV x 1
- For MSSA
Special Populations
Contraindications
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 20-60 minutes (prolonged in neonates and renal impairment)
- Metabolism:
- Excretion:
- Mechanism of Action:
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
Source
- ↑ IDSA/PIDS, 2011
- ↑ Sanford Guide to Antimicrobial Therapy 2014