United States Antibiogram

(Redirected from Antibiotic Sensitivities)

Gram Positives[1]

Category Organism Strep. Group A, B, C, G Strep. Pneumoniae Viridans strep Strep. anginosus gp Enterococcus faecalis Enterococcus faecium MSSA MRSA CA-MRSA Staph. Epidermidis C. jeikeium L. monocytogenes
Penicillins Penicillin G S S I S S I R R R R R S
Penicillin V S S I S S I R R R R R R
Anti-Staphylocccal Penicillins Methicillin S S I S R R S R R S R R
Nafcillin/Oxacillin S S I S R R S R R S R R
Cloxacillin/Diclox. S S I S R R S R R S R R
Amino-Penicillins AMP/Amox S S I S S I R R R R R S
Amox-Clav S S I S S S S R R R R X2
AMP-Sulb S S I S S S S R R R R S
Anti-Pseudomonal Penicillins Ticarcillin S S I S I I R R R I R S
Ticar-Clav S S I S I I S R R I R X2
Pip-Tazo S S I S S I S R R S X1 X2
Piperacillin S S I S S I R R R R R S
Carbapenems Doripenem S S S S I R S R R S X1 S
Ertapenem S S S S R R S R R S R I
Imipenem S S S S S I S R R S R S
Meropenem S S S S I R S R R S X1 S
Aztreonam R R R R R R R R R R R R
Fluroquinolones Ciprofloxacin I I R R U R S R I S R S
Ofloxacin I I R R U R S R X1 S R R
Pefloxacin R R X1 X1 R R S R X1 S X1 R
Levofloxacin S S S S S R S R I S X1 S
Moxifloxacin S S S S S I S I I S X1 S
Gemifloxacin S S S S S I S I I S X1 S
Gatifloxacin S S S S S I S I I S X1 S
1st G Cephalo Cefazolin S S S X1 R X1 S R R I R R
2nd G. Cephalo Cefotetan S S S X1 R X1 S R R I R R
Cefoxitin S S S X1 R X1 S R R I R R
Cefuroxime S S S X1 R X1 S R R I R R
3rd/4th G. Cephalo Cefotaxime S S S X1 R X1 S R R I R R
Cefizoxime S S S X1 R X1 S R R I R R
CefTRIAXone S S S X1 R X1 S R R I R R
Ceftaroline S S S X1 S X1 S S S S X1 X1
CefTAZidime S S I X1 R X1 I R R I R R
Cefepime S S S X1 R X1 S R R I X1 R
Oral 1st G. Cephalo Cefadroxil S S S X1 R X1 S R R I R R
Cephalexin S S S X1 R X1 S R R I R R
Oral 2nd G. Cephalo Cefaclor/Loracarbef S S S X1 R X1 S R R I R R
Cefproxil S S R X1 R X1 S R R I R R
Cefuroxime axetil S S S X1 R X1 S R R I R R
Oral 3rd G. Cephalo Cefixime S S S X1 R X1 R R R R R R
Ceftibuten S I R X1 R X1 R R R R R R
Cefpodox/Cefdinir/Cefditoren S S S X1 R X1 S R R I X1 R
Aminoglycosides Gentamicin R R X1 X1 S S S R X1 I R S
Tobramycin R R X1 X1 S R S R X1 I R S
Amikacin R R X1 X1 S R S R X1 I R S
Chloramphenicol S S X1 X1 I I I R X1 R R S
Clindamycin S S X1 X1 R R S R I R R X1
Macrolides Erythromycin I I X1 X1 R R I R I I R S
Azithromycin I I X1 X1 R R S R I R R S
Clarithromycin I I X1 X1 R R S R I R R S
Ketolide Telithromycin S S X1 X1 I R S R I R R S
Tetracyclines Doxycycline I S X1 X1 R R I I S R R S
Minocycline S S X1 X1 R R S I S R R S
Glycylcycline Tigecycline S S X1 X1 S S S S S S S S
Daptomycin S X23 X1 X1 S S S S S S S I
Glyco/Lipoclycopeptides Vancomycin S S X1 X1 S I S S S S S S
Teicoplanin S S X1 X1 S I S S S I S S
Telavancin S S X1 X1 S S S S S S S S
Fusidic Acid I I X1 X1 S X1 S S S S S X1
Trimethoprim S I X1 X1 S R I I S S R S
TMP-SMX X22 S X1 X1 X22 R S S S I R S
Urinary Agents Nitrofurantoin S S X1 X1 S S S S S X1 R X1
Fosfomycin X1 S X1 X1 S I S S S X1 X1 R
Other Rifampin S S X1 X1 I R S S S S S S
Metronidazole R R X1 X1 R R R R R R R R
Quinupristin dalfoppristin S S X1 X1 R S S S S S S S
Linezolid S S X1 X1 S S S S S S S S
Colistimethate R R X1 X1 R R R R R R R R

Gram Negatives

Category Organism N. gonorrhoeae N. meningitidis Moraxella catarrhalis H. influenzae E. coli Klebsiella sp E. coli/Klebsiella ESBL+ E coli/Klebsiella KPC+ Enterobacter sp, AmpC neg Enterobacter sp, AmpC pos Serratia sp Serratia marcescens Salmonella sp Shigella sp Proteus mirabilis Proteus vulgaris Providencia sp. Morganella sp. Citrobacter freundii Citrobacter diversus Citrobacter sp. Aeromonas sp Acinetobacter sp. Pseudomonas aeruginosa Burkholderia cepacia Stenotrophomonas maltophilia Yersinia enterocolitica Francisella tularensis Brucella sp. Legionella sp. Pasteurella multocida Haemophilus ducreyi Vibrio vulnificus
Penicillins Penicillin G R S R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R S S X1
Penicillin V R R R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R S X1 X1
Anti-Staphylocccal Penicillins Methicillin R R R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R R X1 X1
Nafcillin/Oxacillin R R R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R R X1 X1
Cloxacillin/Diclox. R R R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R R X1 X1
Amino-Penicillins AMP/Amox R S R I I R R R R R R X1 I I S R R R R R R R R R R R R X1 X1 R S R X1
Amox-Clav S S S S S S R R R R R X1 S S S S S I R R R S R R R R I X1 X1 R S S X1
AMP-Sulb S S S S S S R R R R R X1 S S S S S S R R R S S R R R I X1 X1 R S S X1
Anti-Pseudomonal Penicillins Ticarcillin X2 S R I I R R R S S R X1 S S S S S S S S S S R S R X1 I X1 X1 R S X1 X1
Ticar-Clav X2 S S S S S R R S S S X1 S S S S S S S S S S I S X1 S S X1 X1 R S X1 X1
Pip-Tazo X2 S S S S S R R S S S X1 S S S S S S S S S S I S X1 I X1 X1 X1 R X1 X1 X1
Piperacillin X2 S I I S S R R S S S X1 S S S S S S S S S S R S X1 I S X1 X1 R S X1 X1
Carbapenems Doripenem X2 S S S S S S R S S S X1 S S S S S S S S S S I S I R S X1 X1 R S X1 X1
Ertapenem X2 S S S S S S R S S S X1 S S S S S S S S S S R R R R X1 X1 X1 R S X1 X1
Imipenem X2 S S S S S S R S S S X1 S S S S S S S S S S I S R R S X1 X1 R S X1 X1
Meropenem X2 S S S S S S R S S S X1 S S S S S S S S S S I S S R X1 X1 X1 R X1 X1 X1
Aztreonam S S S S S S R R S S S X1 X1 S S S S S S S S S R S R R S X1 X1 R S X1 X1
Fluroquinolones Ciprofloxacin I S S S S S S R S S S X1 S S S S S S S S S S I S R R S X1 X1 S S X1 X1
Ofloxacin I S S S S S S R S S S X1 S S S S S S S S S S I I R R S X1 X1 S S X1 X1
Pefloxacin I S S S S S S R S S S X1 S S S S S S S S S X1 X1 X1 X1 R S X1 X1 S S X1 X1
Levofloxacin I S S S S S S R S S S X1 S S S S S S S S S S I I X1 I S X1 X1 S S X1 X1
Moxifloxacin I S S S S S S R S S S X1 S S S S S S S S S S I I R I S X1 X1 S S X1 X1
Gemifloxacin I X1 S S S S S R S S X1 X1 X1 X1 X1 S X1 X1 X1 X1 X1 X1 I X1 X1 X1 X1 X1 X1 S X1 X1 X1
Gatifloxacin I S S S S S S R S S S X1 S S S S S S S S S S I I R I S X1 X1 S S X1 X1
1st G Cephalo Cefazolin S R I S S S R R R R R X1 X1 X1 S R R R R R R R R R R R R X1 X1 R X1 X1 X1
2nd G. Cephalo Cefotetan I I S S S S R R I R S X1 X1 X1 S S S S R I I S R R R R I X1 X1 R S X1 X1
Cefoxitin I I S S S S R R R R R X1 X1 X1 S S S S R I I I R R R R I X1 X1 R X1 S X1
Cefuroxime I S S S S S R R I R R X1 X1 X1 S S R I R I I S R R R R I X1 X1 R S X1 X1
3rd/4th G. Cephalo Cefotaxime I S S S S S R R S R S X1 S S S S S S S S S S R R I R S X1 X1 R S S X1
Cefizoxime I I S S S S R R S R S X1 S S S S S S R S S S R R I R S X1 X1 R S S X1
CefTRIAXone I S S S S S R R S R S X1 S S S S S S S S S S R R I R S X1 X1 R S S X1
Ceftaroline I S S S S S R R S R S X1 S S S S S S X1 S S S X1 R R R X1 X1 X1 R X1 X1 X1
CefTAZidime I I S S S S R R S R S X1 S S S S S S R S S S I S S I I X1 X1 R X1 S X1
Cefepime I S S S S S R R S R S X1 S S S S S S S S S S I S I R S X1 X1 R S X1 X1
Oral 1st G. Cephalo Cefadroxil R R R X1 S S R R R R R X1 R R S R R R R R X1 X1 R R R R X1 X1 X1 R X1 X1 X1
Cephalexin R R R R S S R R R R R X1 R R S R R R R R R X1 R R R R X1 X1 X1 R R X1 X1
Oral 2nd G. Cephalo Cefaclor/Loracarbef I I I S S S R R R R R X1 X1 X1 S R R R R R I X1 R R R R X1 X1 X1 R X1 X1 X1
Cefproxil I I S S S S R R R R R X1 X1 X1 S R R R R R R X1 R R R R X1 X1 X1 R X1 X1 X1
Cefuroxime axetil I I S S S S R R R R R X1 X1 X1 S R S I R X1 I X1 R R R R X1 X1 X1 R X1 X1 X1
Oral 3rd G. Cephalo Cefixime S I S S S S R R R R I X1 S S S S S R R X1 S S R R R R S X1 X1 R S S X1
Ceftibuten I I S S S S R R I R I X1 S S S S S R R S S S R R S R S X1 X1 R X1 X1 X1
Cefpodox/Cefdinir/Cefditoren S X1 S S S S R R R R R X1 S S S I X1 R R X1 S X1 X1 R X1 X1 X1 X1 X1 R S X1 X1
Aminoglycosides Gentamicin R R S S S S S R S S X1 S X1 S X1 S X1 X1 X1 X1 X1 X1 R S R R S S S+ X1 X1 X1 I
Tobramycin R R S S S S S R S S X1 S X1 S X1 S X1 X1 X1 X1 X1 X1 R S R R S S S+ X1 X1 X1 I
Amikacin R R S S S S S R S S X1 S X1 S X1 S X1 X1 X1 X1 X1 X1 I S R R S S S+ X1 X1 X1 I
Chloramphenicol S S S S S I I R R R X1 R S S X1 I X1 X1 X1 X1 X1 X1 R R S S S S S X1 X1 X2 X2
Clindamycin R R R R R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R X1 X1 X2 X1
Macrolides Erythromycin I X2 I I R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R S X1 S X1
Azithromycin I X2 S S R R R R R R X1 R I I X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R S X1 S X1
Clarithromycin I X1 S S R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R S X1 X1 X1
Ketolide Telithromycin X2 X2 S S R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R X2 X1 X1 X1
Tetracyclines Doxycycline I S S S S I I R R R X1 R I I X1 R X1 X1 X1 X1 X1 X1 R R R X2 R S S X2 X1 R S+
Minocycline I S S S S I I R R R X1 R I I X1 R X1 X1 X1 X1 X1 X1 S R I R R X1 S X2 X1 R S+
Glycylcycline Tigecycline X2 X1 S S S S S S S S X1 S S S X1 I X1 X1 X1 X1 X1 X1 I R I S X1 X1 X1 X2 X1 X1 X1
Daptomycin R R R R R R R R R R X1 R R X1 X1 R X1 X1 X1 X1 X1 X1 R R R R R R R R X1 R R
Glyco/Lipoclycopeptides Vancomycin R R X1 X1 R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R X1 X1 R X1 X1 R X1
Teicoplanin R R X1 X1 R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R X1 X1 R X1 X1 X1 X1
Telavancin R R X1 X1 R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R X1 X1 R X1 X1 X1 X1
Fusidic Acid S S X1 X1 R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 X1 I X1 X1 R
Trimethoprim R I X1 I S I I R I I X1 R I I X1 R X1 X1 X1 X1 X1 X1 R R S R X1 X1 X2 S X1 R X1
TMP-SMX I X2 S I I I I R X1 X1 X1 I I I X1 R X1 X1 X1 X1 X1 X1 I R S S S S X2 S X1 I X1
Urinary Agents Nitrofurantoin S X1 X1 X1 S I X1 R I I X1 R S S X1 R X1 X1 X1 X1 X1 X1 X1 R R R X1 X1 X1 X1 X1 X1 X1
Fosfomycin X1 X1 X1 X1 S S S S S S X1 S S X1 X1 S X1 X1 X1 X1 X1 X1 R R X1 X1 X1 X1 X1 X1 X1 X1 X1
Other Rifampin X2 S S S R R R I R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R X1 X1 S S+ X1 X1 X1 X1
Metronidazole R R R R R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R R R R X1 R R
Quinupristin dalfoppristin X2 R S I R R R R R R X1 X1 R R X1 X1 X1 X1 X1 X1 X1 X1 X1 R X1 X1 X1 X1 X1 X1 X1 X1 X1
Linezolid X1 R I I R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R R R X1 X1 X1 X1
Colistimethate R R X1 X1 S S S S S S X1 R X1 X1 X1 R X1 X1 X1 X1 X1 X1 S S R I X1 X1 X1 X1 X1 X1 X1

Non-Culture Growing Bacteria (Misc)

Category Organism Chlamydophila sp Mycoplasm pneumoniae Rickettsia sp Mycobacterium avium
Penicillins Penicillin G R R X1 X1
Penicillin V R R X1 X1
Anti-Staphylocccal Penicillins Methicillin R R X1 X1
Nafcillin/Oxacillin R R X1 X1
Cloxacillin/Diclox. R R X1 X1
Amino-Penicillins AMP/Amox R R X1 X1
Amox-Clav R R X1 X1
AMP-Sulb R R X1 X1
Anti-Pseudomonal Penicillins Ticarcillin R R X1 X1
Ticar-Clav R R X1 X1
Pip-Tazo R R X1 X1
Piperacillin R R X1 X1
Carbapenems Doripenem R R X1 X1
Ertapenem R R X1 X1
Imipenem R R X1 X1
Meropenem R R X1 X1
Aztreonam R R X1 X1
Fluroquinolones Ciprofloxacin S S X1 X1
Ofloxacin S S X1 X1
Pefloxacin S S X1 X1
Levofloxacin S S X1 X1
Moxifloxacin S S X1 X1
Gemifloxacin S S X1 X1
Gatifloxacin S S X1 X1
1st G Cephalo Cefazolin X1 X1 X1 X1
2nd G. Cephalo Cefotetan X1 X1 X1 X1
Cefoxitin X1 X1 X1 X1
Cefuroxime X1 X1 X1 X1
3rd/4th G. Cephalo Cefotaxime X1 X1 X1 X1
Cefizoxime X1 X1 X1 X1
CefTRIAXone X1 X1 X1 X1
Ceftaroline X1 X1 X1 X1
CefTAZidime X1 X1 X1 X1
Cefepime X1 X1 X1 X1
Oral 1st G. Cephalo Cefadroxil X1 X1 X1 X1
Cephalexin X1 X1 X1 X1
Oral 2nd G. Cephalo Cefaclor/Loracarbef X1 X1 X1 X1
Cefproxil X1 X1 X1 X1
Cefuroxime axetil X1 X1 X1 X1
Oral 3rd G. Cephalo Cefixime X1 X1 X1 X1
Ceftibuten X1 X1 X1 X1
Cefpodox/Cefdinir/Cefditoren X1 X1 X1 X1
Aminoglycosides Gentamicin R R R X1
Tobramycin R R R X1
Amikacin R R R S
Chloramphenicol S S S X1
Clindamycin I R X1 X1
Macrolides Erythromycin S S I X1
Azithromycin S S X1 S
Clarithromycin S S X1 S
Ketolide Telithromycin S S S X1
Tetracyclines Doxycycline S S S R
Minocycline S S S R
Glycylcycline Tigecycline S S X1 R
Daptomycin X1 X1 X1 X1
Glyco/Lipoclycopeptides Vancomycin X1 X1 R X1
Teicoplanin X1 X1 R X1
Telavancin X1 X1 R X1
Fusidic Acid R R R X1
Trimethoprim R X1 X1 X1
TMP-SMX X1 X1 X1 X1
Urinary Agents Nitrofurantoin R X1 X1 X1
Fosfomycin X1 X1 X1 X1
Other Rifampin X2 X1 X1 X1
Metronidazole R R R R
Quinupristin dalfoppristin X2 S X1 R
Linezolid X2 R X1 R
Colistimethate X1 X1 X1 X1

Anaerobes

Category Organism Actinomyces Bacteroides fragilis Prevotella melaninogenica Clostridium difficile Clostridium (not difficile) Fusobacterium necrophorum Peptostreptococcus sp.
Penicillins Penicillin G S R S X2 S I S
Penicillin V I I R X1 S I S
Anti-Staphylocccal Penicillins Methicillin R R R X1 X1 X1 S
Nafcillin/Oxacillin R R R X1 X1 X1 S
Cloxacillin/Diclox. R R R X1 X1 X1 S
Amino-Penicillins AMP/Amox S R S X1 S S S
Amox-Clav S S S X1 S S S
AMP-Sulb S S S X2 S S S
Anti-Pseudomonal Penicillins Ticarcillin X1 R S X1 S X1 S
Ticar-Clav X1 S S X1 S S S
Pip-Tazo X1 S S X1 S S S
Piperacillin S R S X2 S X1 S
Carbapenems Doripenem X1 S S X2 S S S
Ertapenem S S S X2 S S S
Imipenem S S S X2 S S S
Meropenem X1 S S X2 S S S
Aztreonam R R R R R X1 R
Fluroquinolones Ciprofloxacin R R R R I X1 I
Ofloxacin I R I X1 I X1 I
Pefloxacin X1 R X1 X1 X1 X1 X1
Levofloxacin X1 R S R S X1 S
Moxifloxacin S I S R I I S
Gemifloxacin X1 R X1 X1 X1 X1 X1
Gatifloxacin S I S R S X1 S
1st G Cephalo Cefazolin X1 R X1 X1 X1 X1 X1
2nd G. Cephalo Cefotetan X1 I S X1 S X1 S
Cefoxitin X1 S S R S S S
Cefuroxime X1 R S X1 S X1 S
3rd/4th G. Cephalo Cefotaxime X1 R S R S X1 S
Cefizoxime S I S R S X1 S
CefTRIAXone S R I X1 S X1 S
Ceftaroline X1 R X1 X1 X1 X1 X1
CefTAZidime X1 R S X1 S X1 S
Cefepime X1 R R R X1 X1 S
Oral 1st G. Cephalo Cefadroxil X1 X1 X1 X1 X1 X1 X1
Cephalexin X1 R X1 X1 X1 X1 S
Oral 2nd G. Cephalo Cefaclor/Loracarbef X1 R S X1 X1 X1 S
Cefproxil X1 R S X1 S X1 S
Cefuroxime axetil X1 R S X1 S X1 S
Oral 3rd G. Cephalo Cefixime X1 R S X1 R X1 S
Ceftibuten X1 R X1 X1 X1 X1 X1
Cefpodox/Cefdinir/Cefditoren X1 X1 X1 X1 X1 X1 X1
Aminoglycosides Gentamicin R R R R X1 R R
Tobramycin R R R R X1 R R
Amikacin R R R R X1 R R
Chloramphenicol X2 X2 S I S S S
Clindamycin S I S X1 I S S
Macrolides Erythromycin S R X1 X1 I R I
Azithromycin S R S X1 S R S
Clarithromycin S R S X1 S R I
Ketolide Telithromycin X1 X1 X1 X1 X1 X1 S
Tetracyclines Doxycycline S I S X1 S X1 S
Minocycline S I S X1 S X1 S
Glycylcycline Tigecycline X1 S S X1 S S S
Daptomycin X1 X1 X1 X1 X1 X1 X1
Glyco/Lipoclycopeptides Vancomycin S R R S S X1 S
Teicoplanin X1 X1 X1 S S X1 S
Telavancin S R R S S X1 S
Fusidic Acid S X1 S X1 S X1 S
Trimethoprim X1 X2 X1 X1 X1 X1 X1
TMP-SMX X1 R X1 X1 X1 X1 X1
Urinary Agents Nitrofurantoin X1 X1 X1 X1 X1 X1 X1
Fosfomycin X1 X1 X1 X1 X1 X1 X1
Other Rifampin X1 X1 X1 X1 X1 X1 X1
Metronidazole R S S S S+ S I
Quinupristin dalfoppristin X1 X1 S I X2 X1 X1
Linezolid X1 I X1 I X2 X1 S
Colistimethate X1 X1 X1 X1 X1 X1 X1

Key

  • S susceptible/sensitive (usually)
  • I intermediate (variably susceptible/resistant)
  • R resistant (or not effective clinically)
  • S+ synergistic with cell wall antibiotics
  • U sensitive for UTI only (non systemic infection)
  • X1 no data
  • X2 active in vitro, but not used clinically
  • X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
  • X4 active in vitro, but not clinically effective for strep pneumonia

See Also

External Links

References

  1. Sanford Guide to Antimicrobial Therapy 2014

Authors:

Ross Donaldson