Buspirone
Administration
- Type: Anxiolytic
- Dosage Forms:
- Routes of Administration: PO
- Common Trade Names: Buspar
Adult Dosing
- 10-60mg/day divided q8-12h
Pediatric Dosing
- Preadolescent: 2.5-5 mg PO daily
- Adolescent: as adult
Special Populations
Pregnancy Rating
- Category B
Lactation risk
- Excretion in milk unknown/not recommended
Renal Dosing
- Not recommended in severe renal impairment
Hepatic Dosing
- Not recommended in severe hepatic impairment
Contraindications
- Allergy to class/drug
- Concomitant MAOI use
- Severe renal/hepatic impairment
Adverse Reactions
Serious
- Allergic reaction
- Heart failure
- Suicidal ideation
- Increased ocular pressure
- Dystonia
Common
- Dizziness, weakness
- Headache
- Drowsiness, confusion, insomnia, nervousness, dream disturbance, akathisia
- Blurred vision, visual disturbances, photophobia
- Numbness, paresthesia
- Tremor
- Tinnitus
- Nausea, diarrhea, anorexia
- Myalgia
- Rash
- Nasal congestion, sore throat
- Nonspecific chest pain
- Bruising
- Galactorrhea, menstrual irregularity, alopecia
- Syncope
- Eosinophilia
- Edema
- Enuresis
- Rectal bleeding
Pharmacology
- Half-life: 2-3h
- Metabolism: Hepatic
- Excretion: Urinary and in feces
Mechanism of Action
- Unclear exact mechanism; high affinity for serotonin 5HT1A and 5HT2 receptors and moderate affinity for dopamine D2 receptors. No effect on benzodiazepine GABA receptors