Carbon disulfide toxicity

Background

  • Organic Solvent
  • Precursor in rubber industry
  • Also a metabolite of drug Disulfiram

Mechanism of Toxicity

  • Disruption of enzymes and metabolic pathways including in the CNS

Clinical Features

  • Eye irritation
  • Skin irritation
  • CNS depression

Differential Diagnosis

Evaluation

  • Based on clinical history and presenting signs and symptoms

Management

  • Decontaminate
  • Consider activated charcoal for oral ingestions
  • No specific antidotes available

Disposition

See Also

References

  • Olson, K. Poisoning and Drug Overdose, 1999.