Cetacaine

General Information

Cetylite-cetacaine-spray-20g-0220.jpg
  • Brand name of commonly available topical mucosal anesthetic
  • Combination of 14% benzocaine, 2% tetracaine hydrochloride, and 2% butamben
  • Slightly different from another readily available topical anesthetic, HurriCaine spray, which is 20% benzocaine

Administration

  • Type: Topical anesthetic
  • Dosage Forms: Spray, gel, solution
  • Routes of Administration: Mucosal
  • Common Trade Names: Cetacaine; Exactacain

Adult Dosing

Spray form

  • Apply maximum 2 second spray

Gel form

  • Apply a maximum of 1 inch of gel

Solution form

  • Apply a maximum of 0.4cc

Pediatric Dosing

No pediatric dosing established

Special Populations

Renal Dosing

  • Adult: N/A
  • Pediatric: N/A

Hepatic Dosing

  • Adult: N/A
  • Pediatric: N/A

Contraindications

  • Allergy to class/drug
  • Cholinesterase deficincies
  • Use caution in G6PD and Hgb-M patients
  • Avoid using on significantly inflamed or macerated tissue

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: Plasma cholinesterase, liver
  • Excretion: Urine (minimal systemic absorption)

Mechanism of Action

  • Ester anesthetic, inhibits Na ion channels and nerve impulse/conduction

Comments

See Also

References

Micromedex

US FDA benzocaine warning. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm250264.htm