Chronic myeloid leukemia

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  • Also known as chronic myelogenous leukemia, chronic myelocytic leukemia
  • More common in older patients

Clinical Features

Usually progresses through 3 stages

Chronic phase

  • Asymptomatic or indolent, nonspecific symptoms
  • Malaise, fatigue, weight loss, low grade fever
  • Lymphadenopathy, splenomegaly

Accelerated phase

  • Worsening of above symptoms due to progressive leukocytosis
  • Signs/symptoms of thrombocytopenia (e.g. petechiae, bleeding) or thrombocytosis

Blast crisis

Differential Diagnosis

Oncologic Emergencies

Related to Local Tumor Effects

Related to Biochemical Derangement

Related to Hematologic Derangement

Related to Therapy



  • CBC
    • Leukocytosis: usually only moderately elevated in chronic phase (20,000-60,000)
    • Mild-moderate anemia
    • Variable platelet counts
  • Peripheral smear
  • DIC labs: coags, d-dimer, fibrinogen
  • Tumor lysis syndrome labs: BMP, uric acid, phosphate
  • Infectious workup
  • Evaluate for complications



See Also

External Links