Clobetasol
Administration
- Type: Topical steroid
- Dosage Forms: cream, emollient, foam, gel, lotion, ointment, spray, shampoo
- Routes of Administration: topical
- Common Trade Names: Olux, Temovate, Clobex, Cormax
Adult Dosing
- Most indications: apply to affected area of skin BID, max 50g/week
- Genital lichen sclerosus: apply to vulva once daily
- Scalp psoriasis: apply shampoo to affected areas dry scalp once daily; leave in place 15 minutes before lathering and rinsing. Max 50ml/week x 2 weeks
Pediatric Dosing
Safety/efficacy not established in children <12yo
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing:
- Hepatic dosing
Contraindications
- Allergy to class/drug
- Primary scalp infection
Adverse Reactions
Serious
- Secondary hypocortisolism (higher risk in pediatrics)
- Intracranial hypertension
Common
- Skin atrophy, asteatotic eczema
- Skin irritation, burning, discomfort, dryness
- Pruritus
- Telangiectasia
- Upper respiratory infection
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
- High potency synthetic corticosteroid, anti-inflammatory
Comments
See Also
References
- Bae YS, Van Voorhees AS, Hsu S, et al.; National Psoriasis Foundation. Review of treatment options for psoriasis in pregnant or lactating women: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol. 2012;67(3):459-477. doi: 10.1016/j.jaad.2011.07.039. [PubMed 22018758]
- Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014;70(3):417.e1-10; quiz 427. doi: 10.1016/j.jaad.2013.09.009. [PubMed 24528912]
- Carrillo Dde L. Vegetating darier's disease during pregnancy. Acta Derm Venereol. 2006;86(3):259-260. [PubMed 16710592]
- Chi CC, Kirtschig G, Aberer W, et al. Updated evidence-based (S2e) European Dermatology Forum guideline on topical corticosteroids in pregnancy. J Eur Acad Dermatol Venereol. 2017;31(5):761-773. doi: 10.1111/jdv.14101. [PubMed 28233354]
- Chi CC, Wang SH, Kirtschig G. Safety of Topical Corticosteroids in Pregnancy. JAMA Dermatol. 2016;152(8):934-935. doi: 10.1001/jamadermatol.2016.1009. [PubMed 27366995]
- Clobex Lotion (clobetasol) [prescribing information]. Fort Worth, TX: Galderma Laboratories; July 2014.
- Clobex shampoo (clobetasol) [prescribing information]. Fort Worth, TX: Galderma Laboratories; November 2012.
- Clobex Shampoo (clobetasol) [product monograph]. Thornhill, ON: Galderma Canada INC; November 2017.
- Clobex Spray (clobetasol) [product monograph]. Thornhill, ON: Galderma Canada INC; December 2018.
- Clodan (clobetasol) [prescribing information]. Fairfield, NJ: Medimetriks Pharmaceuticals; January 2016.