Clobetasol

Administration

• Type: Topical steroid
• Dosage Forms: cream, emollient, foam, gel, lotion, ointment, spray, shampoo
• Routes of Administration: topical
• Common Trade Names: Olux, Temovate, Clobex, Cormax

Adult Dosing

• Most indications: apply to affected area of skin BID, max 50g/week
• Genital lichen sclerosus: apply to vulva once daily
• Scalp psoriasis: apply shampoo to affected areas dry scalp once daily; leave in place 15 minutes before lathering and rinsing. Max 50ml/week x 2 weeks

Pediatric Dosing

Safety/efficacy not established in children <12yo

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing:
• Hepatic dosing

Contraindications

• Allergy to class/drug
• Primary scalp infection

Adverse Reactions

Serious

• Secondary hypocortisolism (higher risk in pediatrics)
• Intracranial hypertension

Common

• Skin atrophy, asteatotic eczema
• Skin irritation, burning, discomfort, dryness
• Pruritus
• Telangiectasia
• Upper respiratory infection

Pharmacology

• Half-life:
• Metabolism:
• Excretion:

Mechanism of Action

• High potency synthetic corticosteroid, anti-inflammatory

See Also

• Topical steroids

References

• Bae YS, Van Voorhees AS, Hsu S, et al.; National Psoriasis Foundation. Review of treatment options for psoriasis in pregnant or lactating women: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol. 2012;67(3):459-477. doi: 10.1016/j.jaad.2011.07.039. [PubMed 22018758]
• Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014;70(3):417.e1-10; quiz 427. doi: 10.1016/j.jaad.2013.09.009. [PubMed 24528912]
• Carrillo Dde L. Vegetating darier's disease during pregnancy. Acta Derm Venereol. 2006;86(3):259-260. [PubMed 16710592]
• Chi CC, Kirtschig G, Aberer W, et al. Updated evidence-based (S2e) European Dermatology Forum guideline on topical corticosteroids in pregnancy. J Eur Acad Dermatol Venereol. 2017;31(5):761-773. doi: 10.1111/jdv.14101. [PubMed 28233354]
• Chi CC, Wang SH, Kirtschig G. Safety of Topical Corticosteroids in Pregnancy. JAMA Dermatol. 2016;152(8):934-935. doi: 10.1001/jamadermatol.2016.1009. [PubMed 27366995]
• Clobex Lotion (clobetasol) [prescribing information]. Fort Worth, TX: Galderma Laboratories; July 2014.
• Clobex shampoo (clobetasol) [prescribing information]. Fort Worth, TX: Galderma Laboratories; November 2012.
• Clobex Shampoo (clobetasol) [product monograph]. Thornhill, ON: Galderma Canada INC; November 2017.
• Clobex Spray (clobetasol) [product monograph]. Thornhill, ON: Galderma Canada INC; December 2018.
• Clodan (clobetasol) [prescribing information]. Fairfield, NJ: Medimetriks Pharmaceuticals; January 2016.