Colestipol

Administration

  • Type: Bile Acid Binder
  • Dosage Forms: 1 g tab; 5 g/scoop granules; 5 g granule packet
  • Routes of Administration: Oral
  • Common Trade Names: N/A

Adult Dosing

  • Digoxin toxicity, adjunct tx
    • Granules: 5 g PO q6-8h
      • Start: 10 g PO x1 within 1-3h after last oral digoxin ingestion
      • Max: 30 g/day
  • Gallbladder surgery-associated diarrhea, adjunct tx
    • Tabs: 2-16 g/day PO divided QD-QID
      • Start: 2 g PO QD-bid
      • Max: 16 g/day.
      • Do not crush/cut/chew
    • Granules:5-30 g/day PO divided QD-QID
      • Start: 5 g PO QD-bid
      • Max: 30 g/day
  • Hypercholesterolemia
    • Tabs: 2-16 g/day PO divided QD-QID
      • Start: 2 g PO QD-bid
      • Max: 16 g/day.
      • Do not crush/cut/chew
    • Granules:5-30 g/day PO divided QD-QID
      • Start: 5 g PO QD-bid
      • Max: 30 g/day
  • Pruritus secondary to biliary obstruction
    • Tabs: 2-16 g/day PO divided QD-QID
      • Start: 2 g PO QD-bid
      • Max: 16 g/day.
      • Do not crush/cut/chew
    • Granules:5-30 g/day PO divided QD-QID
      • Start: 5 g PO QD-bid
      • Max: 30 g/day

Pediatric Dosing

Pediatric dosing currently unavailable.

Special Populations

  • Pregnancy Rating: C; Inadequate data to assess risk
  • Lactation risk: L3; Safety unknown

Renal Dosing

  • Adult: No adjustment
  • Pediatric: N/A

Hepatic Dosing

  • Adult: Not defined.
  • Pediatric: N/A

Contraindications

  • Allergy to class/drug
  • Caution if constipation
  • Caution if prolonged use

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: N/A
  • Excretion: Feces

Mechanism of Action

Binds intestinal bile acids for excretion.

Comments

See Also

Digoxin toxicity

References