Donepezil

Administration

  • Type: Acetylcholinesterase inhibitor
  • Dosage Forms: Tab: 5 mg, 10 mg, 23 mg; ODT: 5 mg, 10 mg
  • Routes of Administration: Oral
  • Common Trade Names: Aricept

Adult Dosing

Alzheimer dementia, mild-moderate

  • 5 mg PO qhs x4-6wk
    • Increase to 10 mg PO qhs

Alzheimer dementia, moderate-severe

  • 5 mg PO qhs x4-6wk
    • Increase to 10mg PO qhs x3mo, then increase to 23mg PO qhs

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 70h
  • Metabolism: Liver; CYP450: 2D6, 3A4
  • Excretion: Urine, Feces

Mechanism of Action

  • Reversibly binds to and inactivates acetylcholinesterase

Comments

See Also

References