Doxapram
Administration
- Type: Respiratory Stimulator
- Dosage Forms: INJ
- Routes of Administration: IV
- Common Trade Names: Dopram
Adult Dosing
Respiratory depression, postanesthesia
- Intermittent Injection
- 0.5-1 mg/kg IV q5min prn
- Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3g/24h
- 0.5-1 mg/kg IV q5min prn
- Intermittent infusion
- 0.5-1 mg/kg IV
- Max: 4 mg/kg/dose, 3 g/24h
- 0.5-1 mg/kg IV
CNS depression, drug-induced
- Intermittent Injection
- 1-2 mg/kg IV q1-2h prn
- Intermittent infusion
- 1-3 mg/kg/h IV up to 2h
Acute hypercapnia, COPD-assoc.
- 1-3 mg/min IV up to 2h
Pediatric Dosing
Respiratory depression, postanesthesia
- Intermittent Injection
- 0.5-1 mg/kg IV q5min prn
- Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3g/24h
- 0.5-1 mg/kg IV q5min prn
- Intermittent infusion
- 0.5-1 mg/kg IV
- Max: 4 mg/kg/dose, 3 g/24h
- 0.5-1 mg/kg IV
CNS depression, drug-induced
- Intermittent Injection
- 1-2 mg/kg IV q1-2h prn
- Intermittent infusion
- 1-3 mg/kg/h IV up to 2h
Special Populations
- Pregnancy Rating: C
- Lactation risk: No current data to asses risk
Renal Dosing
- Adult: Caution advised in significant impairment
- Pediatric: Caution advised in significant impairment
Hepatic Dosing
- Adult: Caution advised in significant impairment
- Pediatric: Caution advised in significant impairment
Contraindications
- Allergy to class/drug
- Concurrent mechanical ventilation
- Mechanical disorders of ventilation
- Seizure disorder
- Pulmonary embolism
- Head injury
- Stroke
- Cerebral edema
- Cardiovascular impairment, Heart failure, HTN
Adverse Reactions
Serious
- Bronchospasm, laryngospasm
- Arrhythmia
- HTN
- Seizure
- Hallucinations
- Hemolysis with rapid infusion
Common
- Fever, flushing, diaphoresis
- Pruritis, parasthesia
- Mydriasis
- Hallucination
- Headache, dizziness
- Hyperactivity, involuntary movements, muscle spasms
- Seizure
- Dyspnea, cough, hyperventilation, tachypnea
- Phlebitis
- Diarrhea, Urinary incontinence, urinary retention
Pharmacology
- Half-life: 3.4h
- Metabolism: Liver
- Excretion: Urine (<5% unchanged)
Mechanism of Action
- Acts on peripheral carotid chemoreceptors to stimulate respiration