Flunitrazepam toxicity

Background

• Also known as Rohypnol
• Used in Europe and Asia for Insomnia and Pre-op sedation
• Used in US as "date-rape" agent
• An intermediate acting benzodiazepine
• Has strong affinity for benzodiazepine receptor

Clinical Features

• CNS depression within 30 minutes
• Patients can usually be aroused with noxious stimuli
• Half life 16-35 hours but coma can last 48h

Differential Diagnosis

Sedative/hypnotic toxicity

• Absinthe
• Barbiturates
• Benzodiazepines
  • Flunitrazepam (Rohypnol)
• Chloral hydrate
• Gamma hydroxybutyrate (GHB)
• Baclofen toxicity
• Opioids
  • Lomotil toxicity
  • Loperamide toxicity
• Toxic alcohols
  • Ethanol
  • Ethylene glycol
  • Isopropyl alcohol
  • Methanol
• Xylazine toxicity

See Also

• Benzodiazepines
• Sedative/hypnotic toxicity